“Early Immunologic Changes During the Onset of Atopic Dermatitis”

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, characterized by a fluctuating course, intense itch, and strongly inflamed skin lesions,1 putatively caused by a complex interaction of genetic, immune and environmental factors.2 AD is a highly heritable disease, showing strong associations with filaggrin (FLG) gene null mutations and Th2 signaling pathways,2 that have implications for epithelial barrier and skin inflammatory properties in affected individuals, respectively.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research