Recent Diagnosis Techniques in Pediatric Asthma
Objective measures of lung function are important in the diagnosis and management of asthma. Spirometry, the pulmonary function test most widely used in asthma, requires respiratory maneuvers that may be difficult for preschoolers. Impulse oscillometry (IOS) is a noninvasive method of measuring lung function during tidal breathing; hence, IOS is an ideal test for use in preschool asthma. Fractional exhaled nitric oxide (FeNO) levels correspond to eosinophilic inflammation and predict responsiveness to corticosteroids. Basic concepts of IOS, methodology, and interpretation, including available normative values, and recent findings regarding FeNO are reviewed in this article.
This study supports a positive benefit-risk profile for long-term mepolizumab treatment in these patients.
Publication date: Available online 14 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Maxime Cormier, Simone Chaboillez, Catherine Lemière
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Neutrophilic inflammation in asthma is associated with interleukin (IL)-17A, corticosteroid-insensitivity and bronchodilator-induced forced expiratory volume in 1 s (FEV1) reversibility. IL-17A synergises with tumour necrosis factor (TNF)-α in the production of the neutrophil chemokine CXCL-8 by primary bronchial epithelial cells (PBECs). We hypothesised that local neutrophilic inflammation in asthma correlates with IL-17A and TNF-α-induced CXCL-8 production by PBECs from asthma patients. PBECs from most asthma patients displayed an exaggerated CXCL-8 production in response to TNF-α and IL-17A, but n...
Asthma is a chronic disease that seriously harms the health of patients. Oxidative stress is involved in asthma. As an oxidative stress-inducible protein, sestrin2 is elevated in oxidative stress-related disea...
Severe Combined Immune Deficiency (SCID) is the first primary immunodeficiency amenable to population based newborn screening (NBS) and is now available in all 50 states and Puerto Rico. NBS for SCID uses real time qPCR to measure the number of copies of T cell restriction excision circles (TREC) in DNA from newborn dried blood spots (DBS) and reliably detects severe T cell lymphopenia (TCL) at birth. SCID is the primary condition detected using this assay. However, it is well known that many secondary conditions, having varying degrees of TCL, are identified through SCID NBS.
It is well established that there are significant benefits of prescribing beta-lactam antibiotics for susceptible infections. Prescription of non-beta-lactam antibiotics in inpatients with penicillin allergy labels is associated with increased hospital days (1), increased cost of admission (1, 2), increased readmissions (3), increased intensive care unit admissions, increased multi-resistant organisms (MROs) (1), and increased mortality (4).
PMID: 31419490 [PubMed - as supplied by publisher]