Left ventricular lusitropy and primary graft dysfunction in lung transplantation

Primary graft dysfunction (PGD) is a major cause of morbidity and mortality after lung transplantation. Its incidence has decreased with optimization of lung preservation strategies. It remains, however, an important problem, particularly in patients with pulmonary fibrosis and pulmonary hypertension.1 Its development is generally multifactorial and thus referred to as a syndrome. Biologically, activation of the innate immune system and increased endothelial permeability are the main drivers of pulmonary capillary leak after reperfusion.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research