Making Procurement Biopsies Important Again for Kidney Transplant Allocation

In this study, procurement biopsies were frozen and read by on-call pathologists, often with no specific training in renal pathology, while reperfu sion sections were paraffin embedded and scored by experienced renal pathologists at Columbia University, New York, NY, USA. This methodological difference per se represents an obvious explanation for the poor concordance between the 2 assessments. Use of wedge biopsies in procurement samples versus core-needle samples in reperfusion biopsies may further account for the discrepancies between scores even in seemingly objective measurements, such as the percentage of glomerulosclerosis. Therefore, these data should not mislead us regarding the importance of procurement biopsies to define organ s uitability for transplantation. Rather, they should prompt more studies aimed at optimizing the strategies to score these samples properly for optimal organ allocation.Nephron 2019;142:1 –6
Source: Nephron - Category: Urology & Nephrology Source Type: research