The association between diabetes and age at the onset of menopause: a systematic review protocol

AbstractBackgroundAge at the onset of menopause is the most important determinant of women ’s future health outcomes. While the basic mechanisms contributing to the onset of menopause are still not fully understood, age at menopause depends on a complex set of various factors. In this regard, the effects of diabetes (DM I/II) on the age at the onset of menopause have received little att ention.Methods and analysisElectronic databases including PubMed/MEDLINE, Web of Science, Scopus, EMBASE, and Google Scholar will be searched for articles published during January 2000 to August 2018 and containing combinations of related MeSH terms, i.e., “age at menopause” and “diabetes.” Additional studies will also be extracted from the reference lists of the selected papers, gray literature, and key journals in the field. A set of inclusion criteria will be defined, and all eligible observational studies will be included. Two reviewers wi ll independently conduct the study selection, data extraction, and quality assessment of the selected studies. All cases of disagreement will be resolved through consensus. The methodological assessment of the primary studies will be performed based on the Newcastle-Ottawa Scale (NOS). In case of th e availability of sufficient data, fixed or random effects models will be used to combine all data. Heterogeneity will be assessed byI2 statistic and chi-square test. Stata V.11.1 will be used for data analysis (CRD42017080789).E...
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research

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(Reuters Health) - Women with type 2 diabetes may face more sleep issues and more severe sleep troubles during menopause than peers without diabetes, a small study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
WEDNESDAY, Aug. 21, 2019 -- Middle-aged women with type 2 diabetes mellitus (T2DM) have more sleep disturbances than women without diabetes, even when accounting for menopause and other health issues, according to a study published online Aug. 12 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
WEDNESDAY, Aug. 21, 2019 -- Postmenopausal women with normoglycemia with a first-degree family history of diabetes (FHD) have elevated bone mineral density (BMD), according to a study published online Aug. 19 in Menopause. Lijuan Yang, M.D., from...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Changes in oestrogen and progesterone levels during menopause can affect glucose regulation and lead to sleep disturbances, which are more pronounced in women with diabetes, according to a study published inMenopause.Medical Xpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Conclusion.Results of this study suggest that inhibition of estrogen synthesis in postmenopausal women undergoing treatment with aromatase inhibitors could increase the risk of NAFLD, which might have some influence on the prognosis of patients with breast cancer.Implications for Practice.Unlike tamoxifen, the role of aromatase inhibitor treatment use in postmenopausal patients with breast cancer in development of fatty liver is not well known. In this propensity‐matched cohort study, postmenopausal patients with breast cancer treated with aromatase inhibitors had increased risk of nonalcoholic fatty liver disease compar...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
Abstract OBJECTIVE: To assess the long-term outcome of post-menopausal women diagnosed with non-atypical endometrial hyperplasia (NEH). METHODS: It is a retrospective study of women aged 55 and older who underwent endometrial sampling in our large academic medical center between 1997 and 2008. Women diagnosed with NEH were included in the study group and were compared to women diagnosed with atrophic endometrium on endometrial sampling. Outcome data was obtained through February 2018. The main outcomes were the risk of progression to endometrial carcinoma and the risk of persistent endometrial hyperplasia (EH...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
In conclusion, sex differences in the cardiovascular system are because of dissimilarities in gene expression and sex hormones; these result in variations in prevalence and presentation of CVD and associated conditions, such as diabetes, hypertension and vascular and cardiac remodeling. Changes in lifestyle and increase in physical activity could help in prevention of cardiovascular disease in women.
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Position paper Source Type: research
Conclusions: We found an inverse association of stature with DM but not with HBP. Our data suggest that urban setting might be an important effect modifier of this association, which merits further investigation since it might provide valuable insights into the epidemiological transition occurring in developing countries. PMID: 31363354 [PubMed]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
CONCLUSIONS: In this large cohort of post-menopausal US women, daily NO2 and NOx were associated with higher risk of hemorrhagic stroke, but ambient levels of four other air pollutants were not associated with higher risk of total stroke, ischemic stroke, or ischemic stroke subtypes. PMID: 31382185 [PubMed - as supplied by publisher]
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
Testosterone treatment in post-menopausal women can improve symptoms of sexual dysfunction, according to research published in theLancet Diabetes& Endocrinology.Reuters
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
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