TNF- α Upregulates IKKε Expression via the Lin28B/let-7a Pathway to Induce Catecholamine Resistance in Adipocytes.

CONCLUSIONS: Adipose IKKε expression in children with obesity is substantially elevated and positively correlated with BMI. TNF-α induces catecholamine resistance via activation of the Lin28B/let-7a/IKKε pathway.
PMID: 30933434 [PubMed - as supplied by publisher]

Source: Obesity - March 31, 2019 Category: Eating Disorders & Weight Management Authors: Li M, Wang M, Liu Y, Huang S, Yi X, Yin C, Wang S, Zhang M, Yu Q, Li P, Xiao Y Tags: Obesity (Silver Spring) Source Type: research