Profound weight loss induces reactive astrogliosis in the arcuate nucleus of obese mice

ConclusionsOverall, our data demonstrate that in a chronically obese state, astrocyte and microglial RG is indifferent from that observed in age-matched chow controls. Nonetheless, profound acute weight loss can induce astrocyte RG in the hypothalamic arcuate nucleus, possibly due to increased circulating NEFAs. This suggests that astrocytes may sense acute changes to both the dietary environment and body weight.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research