Metabolic Acidosis in Postsurgical Patient on Canagliflozin and Metformin: A Case Report

Canagliflozin is a novel drug for diabetes mellitus with the mechanisms of inducing glucosuria through inhibition of the sodium-glucose cotransporter 2 in the kidney independent of insulin activity. We are reporting euglycemic ketoacidosis with severe life-threatening metabolic acidosis. The 2 patients described had type 2 diabetes mellitus and were in a state of relative starvation after abdominal surgery. The first patient had been given an oral diet but was restricted with regard to calorie and sugar intake. The second patient had been nil per os since the operation.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports Source Type: research

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Source: BMJ Comments - Category: General Medicine Source Type: forums
ConclusionsMore frequent and regular primary care provider encounters are associated with an increased likelihood of non-insulin diabetes medication adherence. These findings contribute to data needed to establish evidence-based guidelines for primary care provider encounter cadence for those newly diagnosed with type 2 diabetes mellitus.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Condition:   Type2 Diabetes Mellitus Intervention:   Drug: HMS5552 Sponsor:   Majianhua Not yet recruiting
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Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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Authors: PMID: 31525098 [PubMed - in process]
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OMICS: A Journal of Integrative Biology, Ahead of Print.
Source: OMICS: A Journal of Integrative Biology - Category: Biology Authors: Source Type: research
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CONCLUSION: This systematic review and meta-analysis indicated that green tea significantly reduced the circulating levels of CRP, whereas, it had no significant effect on MDA and TAC. Overall, green tea can be considered as a healthy drink to reduce CRP levels in T2DM patients. PMID: 31519281 [PubMed - in process]
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
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