Metabolic Acidosis in Postsurgical Patient on Canagliflozin and Metformin: A Case Report
Canagliflozin is a novel drug for diabetes mellitus with the mechanisms of inducing glucosuria through inhibition of the sodium-glucose cotransporter 2 in the kidney independent of insulin activity. We are reporting euglycemic ketoacidosis with severe life-threatening metabolic acidosis. The 2 patients described had type 2 diabetes mellitus and were in a state of relative starvation after abdominal surgery. The first patient had been given an oral diet but was restricted with regard to calorie and sugar intake. The second patient had been nil per os since the operation.
ConclusionsMore frequent and regular primary care provider encounters are associated with an increased likelihood of non-insulin diabetes medication adherence. These findings contribute to data needed to establish evidence-based guidelines for primary care provider encounter cadence for those newly diagnosed with type 2 diabetes mellitus.
Condition: Type2 Diabetes Mellitus Intervention: Drug: HMS5552 Sponsor: Majianhua Not yet recruiting
This study aimed to identify potential core genes and pathways involved in T2DM, through exhaustive bioinformatic analyses using GSE20966 microarray profiles of pancreatic β‑cells obtained from healthy controls and patients with T2DM. The original microarray data were downloaded from the Gene Expression Omnibus database. Data were processed by the limma package in R software and the differentially expressed genes (DEGs) were identified. Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were carried out to identify potential biological functions and pathways of the DEGs. K...
This study investigated whether periodontal treatment might improve glycemic control in patients with chronic periodontitis and type 2 diabetes mellitus, and which modality offers most benefit.BMC Oral Health
Authors: Karvani M, Simos P, Stavrakaki S, Kapoukranidou D Abstract There is emerging evidence that cognitive impairment could be a diabetes mellitus-related complication. It has been suggested that diabetic people are at increased risk of cognitive decline, since the metabolic and vascular disturbances of the disease affect brain function. Additionally, prolonged exposure to olther potential detrimental factors leads to irreversible cognitive decrements over time due to the aging process. Neurocognitive impairment signifies decreased performance in cognitive domains such as verbal and nonverbal memory, both immedi...
Authors: PMID: 31525098 [PubMed - in process]
OMICS: A Journal of Integrative Biology, Ahead of Print.
Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. Rev Neurol (Paris). 2019 Sep 11;: Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive revi...
CONCLUSION: This systematic review and meta-analysis indicated that green tea significantly reduced the circulating levels of CRP, whereas, it had no significant effect on MDA and TAC. Overall, green tea can be considered as a healthy drink to reduce CRP levels in T2DM patients. PMID: 31519281 [PubMed - in process]