Predictors and burden of hospital readmission with recurrent Clostridioides difficile infection: a French nation-wide inception cohort study

AbstractTo investigate the predictors and burden of hospital readmission with recurrentClostridioides difficile infection (rCDI) in a large European healthcare system with a low prevalence of hyper-virulentC. difficile clones. We conducted an inception cohort study based on an exhaustive health insurance database and including all survivors of a first hospital stay with CDI over a one-year period (2015) in France. Readmissions with rCDI were defined as a novel hospital stay with CDI within 12  weeks following discharge of the index hospitalization. Risk factors for readmission with rCDI were investigated through multivariate logistic regression analyses. Among the 14,739 survivors of the index hospital stay (females, 57.3%; median age, 74 [58–84] years), 2135 (14.5%) required at least one readmission with rCDI. Independent predictors of readmission were age ≥ 65 years (adjusted odds ratio (aOR), 1.34, 95% confidence interval (CI), 1.21–1.49,P <  0.0001), immunosuppression (aOR, 1.27, 95% CI, 1.15–1.41,P <  0.0001), chronic renal failure (aOR, 1.29, 95% CI, 1.14–1.46,P <  0.0001), and a previous history of CDI (aOR, 2.05, 95% CI, 1.55–2.71,P <  0.0001). The cumulative number of risk factors was independently associated with the hazard of readmission. Mean acute care costs attributable to rCDI were 5619 ± 3594 Euros for readmissions with rCDI as primary diagnosis (mean length of stay, 11.3 ± 10.2 days) and 4851 ± 445 E...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research