Gut microbiota in obstructive sleep apnea-hypopnea syndrome: disease-related dysbiosis and metabolic comorbidities
Gut microbiota alterations manifest as intermittent hypoxia and fragmented sleep, thereby mimicking obstructive sleep apnea-hypopnea syndrome (OSAHS). Here, we sought to perform the first direct survey of gut microbial dysbiosis over a range of apnea-hypopnea indices (AHI) among patients with OSAHS. We obtained fecal samples from 93 patients with OSAHS [5
Obstructive sleep apnea (OSA) is associated with an increased risk of developing depression and anxiety in adults, astudy inJAMA Otolaryngology-Head&Neck Surgery has found. OSA is a condition in which the muscles of the throat relax during sleep and block the airway, which causes breathing to stop and start repeatedly throughout the night. Jong-Yeup Kim, M.D., Ph.D., and colleagues at Konyang University in Korea analyzed the health records of 985 adults from the Korea National Health Insurance Service –National Sample Cohort in South Korea database. Between January 2004 and December 2006, 197 patients were d...
In conclusion, even under deep propofol sedation, apneas and hypopneas can be terminated without cortical arousal. However, extensive suppression of the arousal threshold can lead to critical hypoxemia suggesting careful respiratory monitoring.
ConclusionDISE induced significant revision of the location and change in treatment of obstruction sites in children with OSAHS. Systematic implementation, especially in type-I OSAHS, would allow more precise pre-therapeutic classification and treatment adapted to actual airway obstruction.
Condition: Obstructive Sleep Apnea Intervention: Diagnostic Test: biomarkers Sponsor: Assiut University Not yet recruiting
Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, today announced the commercial launch of Philips NightBalance, a prescription sleep position therapy device designed for patients with positional obstructive sleep apnea (OSA).
Abstract OBJECTIVE: To compare the prevalence of increased risk of obstructive sleep apnea (OSA) in children with and without cleft lip and/or palate using a previously validated questionnaire and to examine the clinical and demographic variables that may lead to increased OSA risk. DESIGN: Prospective, cross-sectional study. PARTICIPANTS: One hundred fifty-five cleft lip palate and 155 noncleft children between 2 and 18 years old. INTERVENTIONS: The Pediatric Sleep Questionnaire (PSQ): Sleep Related Breathing Disorder Scale was used for screening of increased OSA risk. Age, body mass index (BMI), g...
Conclusion: Based on the data acquired in the present study, a positive correlation was determined between the accident statuses of drivers with OSAS severity. We want to attract attention to the necessity of evaluating the OSAS symptoms in professional heavy equipment operators during the certification period and at various intervals afterwards, and to carry out OSAS evaluations by PSG for those having a certain risk. PMID: 31533301 [PubMed - in process]
Condition: Obstructive Sleep Apnea Interventions: Drug: TAK-925; Drug: Placebo Sponsor: Millennium Pharmaceuticals, Inc. Not yet recruiting
Authors: De Jong A, Verzilli D, Chanques G, Futier E, Jaber S Abstract The obese patient is at an increased risk of perioperative complications. Most importantly, these include difficult access to the airways (intubation, difficult or impossible ventilation), and post-extubation respiratory distress secondary to the development of atelectasis or obstruction of the airways, sometimes associated with the use of morphine derivatives. The association of obstructive sleep apnea syndrome (OSA) with obesity is very common, and induces a high risk of peri- and postoperative complications. Preoperative OSA screening is cruc...