Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis [Chemistry]

Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage Plasmodium falciparum and Cryptosporidium...

Source: Proceedings of the National Academy of Sciences - April 1, 2019 Category: Science Authors: Beatriz Baragana, Barbara Forte, Ryan Choi, Stephen Nakazawa Hewitt, Juan A. Bueren–Calabuig, Joao Pedro Pisco, Caroline Peet, David M. Dranow, David A. Robinson, Chimed Jansen, Neil R. Norcross, Sumiti Vinayak, Mark Anderson, Carrie F. Brooks, Cait Tags: Biological Sciences Source Type: research