IDEAS study confirms amyloid PET's value for Alzheimer's

There appears to be little doubt about the efficacy of PET scans with an amyloid...Read more on AuntMinnie.comRelated Reading: New PET tracer could better connect tau to Alzheimer's IDEAS study adds 3 new research efforts Brain amyloid imaging study opens patient enrollment IDEAS study to explore amyloid PET and Alzheimer's SNMMI: Amyloid PET clarifies Alzheimer's FDG-PET scans
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

Related Links:

DISCUSSION: Our results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain Aβ production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials. PMID: 31627825 [PubMed - in process]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
We present the theoretical considerations of f-FTLD and the aims/objectives of this protocol. We also describe the design and methodology for evaluating and rating subjects, in which detailed clinical and neuropsychological assessments are performed, biofluid samples are collected, and magnetic resonance imaging scans are performed using a standard protocol.DiscussionThese data and samples, which are available to interested investigators worldwide, will facilitate planning for upcoming disease-modifying therapeutic trials in f-FTLD.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Brain maps based on functional MRI (fMRI) scans are proving useful in predicting...Read more on AuntMinnie.comRelated Reading: Can MRI of healthy brains explain head trauma damage? Advanced MRI technique confirms dementia risk PET, MRI show physical activity aids brain health MRI links brain region to dementia, auditory deterioration DTI-MRI offers window into Alzheimer's risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Researchers at the University of Turku have discovered new changes in blood samples associated with Alzheimer’s disease. A new study was conducted on disease-discordant Finnish twin pairs: one sibling suffering from Alzheimer's disease and the other being cognitively healthy. The researchers used the latest genome-wide methods to examine the twins' blood samples for any disease-related differences in epigenetic marks which are sensitive to changes in environmental factors. These differences between the siblings were discovered in multiple different genomic regions. Development of the late-onset form of Al...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
DiscussionOur results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain Aβ production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
MRI scans of patients with traumatic head injuries have revealed microbleeds...Read more on AuntMinnie.comRelated Reading: Deep-learning model detects cerebral microbleeds on MRI Key MRI markers link vascular brain injury to health risks MRI offers possible link between microbleeds, Alzheimer's Brain MRI offers new insight into blood deposits SIIM: AI can accurately detect cerebral microbleeds
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
A technology that originated at the University of Minnesota is well on its way to commercialization thanks to an investment award from Alzheimer's Drug Discovery Foundation (ADDF). The investment of up to $500,000 was awarded through the ADDF's Diagnostics Accelerator initiative. Toronto, Ontario-based RetiSpec licensed through the University of Minnesota's Technology Commercialization program. The technology (shown on the right) harnesses hyperspectral imaging and machine learning.  RetiSpec Eye Scanner 3.jpeg "We are focused on bringing to market a noninvasiv...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
Conclusion[18F]RO948 and [18F]flortaucipir bound comparably in neocortical regions, but [18F]RO948 showed higher retention in the medial temporal lobe and lower intracerebral “off-target” binding. Time-dependent bias of SUVR estimates may prove less of a factor with [18F]RO948, compared with previous tau ligands.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
ConclusionWe suggest a one-step quantification method for amyloid PET via a deep learning model. The model is highly reliable to quantify the amyloid PET regardless of multicenter images and various radiotracers.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Conditions:   Mild Traumatic Brain Injury;   Moderate Traumatic Brain Injury;   Mild Cognitive Impairment Interventions:   Device: No Intervention is used for this study but all subjects will be asked to complete EEG testing and an MRI scan.;   Procedure: No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure. Sponsor:   VA Boston Healthcare System Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Alzheimer's | Brain | Neurology | PET Scan | Radiology | Study