IDEAS study confirms amyloid PET's value for Alzheimer's
There appears to be little doubt about the efficacy of PET scans with an amyloid...Read more on AuntMinnie.comRelated Reading: New PET tracer could better connect tau to Alzheimer's IDEAS study adds 3 new research efforts Brain amyloid imaging study opens patient enrollment IDEAS study to explore amyloid PET and Alzheimer's SNMMI: Amyloid PET clarifies Alzheimer's FDG-PET scans
DISCUSSION: Our results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain Aβ production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials. PMID: 31627825 [PubMed - in process]
We present the theoretical considerations of f-FTLD and the aims/objectives of this protocol. We also describe the design and methodology for evaluating and rating subjects, in which detailed clinical and neuropsychological assessments are performed, biofluid samples are collected, and magnetic resonance imaging scans are performed using a standard protocol.DiscussionThese data and samples, which are available to interested investigators worldwide, will facilitate planning for upcoming disease-modifying therapeutic trials in f-FTLD.
Brain maps based on functional MRI (fMRI) scans are proving useful in predicting...Read more on AuntMinnie.comRelated Reading: Can MRI of healthy brains explain head trauma damage? Advanced MRI technique confirms dementia risk PET, MRI show physical activity aids brain health MRI links brain region to dementia, auditory deterioration DTI-MRI offers window into Alzheimer's risk
Researchers at the University of Turku have discovered new changes in blood samples associated with Alzheimerâs disease. A new study was conducted on disease-discordant Finnish twin pairs: one sibling suffering from Alzheimer's disease and the other being cognitively healthy. The researchers used the latest genome-wide methods to examine the twins' blood samples for any disease-related differences in epigenetic marks which are sensitive to changes in environmental factors. These differences between the siblings were discovered in multiple different genomic regions. Development of the late-onset form of Al...
DiscussionOur results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain Aβ production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials.
MRI scans of patients with traumatic head injuries have revealed microbleeds...Read more on AuntMinnie.comRelated Reading: Deep-learning model detects cerebral microbleeds on MRI Key MRI markers link vascular brain injury to health risks MRI offers possible link between microbleeds, Alzheimer's Brain MRI offers new insight into blood deposits SIIM: AI can accurately detect cerebral microbleeds
A technology that originated at the University of Minnesota is well on its way to commercialization thanks to an investment award fromÂ Alzheimer's Drug Discovery Foundation (ADDF). The investment of up to $500,000 was awarded through the ADDF's Diagnostics Accelerator initiative. Toronto, Ontario-based RetiSpec licensed through the University of Minnesota'sÂ Technology Commercialization program. The technology (shown on the right) harnessesÂ hyperspectral imaging and machine learning.Â RetiSpec Eye Scanner 3.jpeg "We are focused on bringing to market a noninvasiv...
Conclusion[18F]RO948 and [18F]flortaucipir bound comparably in neocortical regions, but [18F]RO948 showed higher retention in the medial temporal lobe and lower intracerebral “off-target” binding. Time-dependent bias of SUVR estimates may prove less of a factor with [18F]RO948, compared with previous tau ligands.
ConclusionWe suggest a one-step quantification method for amyloid PET via a deep learning model. The model is highly reliable to quantify the amyloid PET regardless of multicenter images and various radiotracers.
Conditions: Mild Traumatic Brain Injury; Moderate Traumatic Brain Injury; Mild Cognitive Impairment Interventions: Device: No Intervention is used for this study but all subjects will be asked to complete EEG testing and an MRI scan.; Procedure: No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure. Sponsor: VA Boston Healthcare System Not yet recruiting