He Married His Kidney Donor. But Now, He Needs Another Kidney

Kyle Froelich’s first search for a donor kidney ended in a fairy tale romance. In 2010, Chelsea Clair decided to give her kidney to Froelich—a man she’d never met—after hearing through a mutual friend that both of his were failing. The pair began seeing each other every day as Clair went through the donor testing process and eventually started dating after the transplant was complete. Kyle’s health returned, and they got married three years later, making headlines across the country. Now, however, the Indiana couple is back in the news for a less celebratory reason: the kidney Chelsea donated is failing. If Kyle doesn’t get a new one within the next year, he says, he’ll be forced to go on dialysis. “We’ve done it before. You have to stay optimistic,” Kyle, 28, says of his second search. “I don’t ever worry about it. I just have faith that it’s going to happen. When it happens, it happens.” The first time around, it happened thanks to Chelsea. At age 12, Kyle was diagnosed with a condition that causes an antibody to collect in his kidneys, resulting in inflammation that makes it difficult for his organs to filter waste products from his blood. By 19, Kyle was in desperate need of a transplant. He began looking for a donor among family and friends, but his type O blood made it difficult to find the right match. Dozens of his loved ones were tested, but none was the right fit. “I’d ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Source Type: news

Related Links:

RARITAN, NJ, June 13, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today results from the first randomized Phase 3 study investigating subcutaneous daratumumab[i] in the treatment of patients with newly diagnosed light chain (AL) amyloidosis, a rare and potentially fatal disease.[1],[2] The data demonstrated subcutaneous daratumumab in combination with cyclophosphamide, bortezomib, and dexamethasone (D-CyBorD) resulted in a higher hematologic complete response rate (CR), (53 percent vs. 18 percent [P
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Rationale: Coronavirus disease 2019 (COVID-19) is a novel infectious disease and became a global issue. Treatment of COVID-19 especially in solid organ transplant recipients is empirical and controversial, especially the adjustment of the immunosuppressants. Patient concerns: A 29-year-old kidney transplant recipient with the symptoms of COVID-19 pneumonia. Diagnoses: COVID-19 pneumonia after kidney transplantation. Interventions: He was treated with modified immunosuppressants (unchanged dose of tacrolimus and oral corticosteroids while discontinuing mycophenolate mofetil (MMF)), antibiotics, interferon α...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
This study aims to assess the anti-inflammatory effects of colchicine in non-severe hospitalized COVID-19 patients.Trial designProspective, randomized (1:1 ratio), double blind study with parallel group design.ParticipantsHospitalized patients with positive nasopharyngeal swab for COVID-19 infection (RT -PCR) and lung Computed tomography scan involvement compatible with COVID-19 pneumonia. The patients are not severely hypoxic, do not need intubation or invasive oxygenation.Exclusion criteria: known hypersensitivity to colchicine; known hepatic failure; estimated glomerular filtration rate (eGFR)450 msec.Participants will ...
Source: Trials - Category: Research Source Type: clinical trials
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Samavat S, Nafar M, Firozan A, Pourrezagholi F, Ahmadpoor P, Samadian F, Ziaei S, Fatemizadeh S, Dalili N Abstract in the reports presented about COVID-19, patients receiving kidney transplantation have not been specifically studied and based on national flowchart, this population is classified as highrisk group, thus it is necessary to be aware of the step-by-step treatment approach of these patients. Suspicious cases included patients with a history of dry cough, chills or sore throat accompanying by shortness of breath with or without fever, patients with upper/lower respiratory symptoms with radiologic...
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease. Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus https://www.fightaging.org/archives/2020/04/notes-on-se...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
A 61-year-old African American man with history of hypertension, coronary artery disease, end-stage renal disease (on hemodialysis since 2014) and end-stage heart failure secondary to arrhythmogenic right ventricular cardiomyopathy (ARVC) underwent dual organ heart-kidney transplantation in May, 2019. Approximately two months after transplant mycophenolate was discontinued due to episodes of pancreatitis, leukopenia and detectable BK polyoma virus. Since then, the patient was maintained on tacrolimus (goal level 8 ng/mL) and low-dose prednisone (5mg/day).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
A 61-year-old African American man with a history of hypertension, coronary artery disease, end-stage renal disease (on hemodialysis since 2014), and end-stage heart failure secondary to arrhythmogenic right ventricular cardiomyopathy underwent dual organ heart –kidney transplantation in May 2019. Approximately 2 months after transplant, mycophenolate was discontinued owing to episodes of pancreatitis, leukopenia, and detectable BK polyomavirus. Since then, the patient was maintained on tacrolimus (goal level of 8 ng/ml) and low-dose prednisone (5 mg/day ).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
We describe 20 kidney transplant recipients (median age 59 years [inter quartile range 51-64 years], median age of transplant 13 years [9-20 years], baseline eGFR 36.5 [23-47.5]) with SARS-CoV2 induced pneumonia. At admission, all had immunosuppression withdrawn and were started on methylprednisolone 16 mg/day, all but one was commenced on antiviral therapy and hydroxychloroquine with doses adjusted for kidney function.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: editorial: special report Source Type: research
We describe 20 kidney transplant recipients (median age 59 years [inter quartile range 51-64 years], median age of transplant 13 years [9-20 years], baseline eGFR 36.5 [23-47.5]) with SARS-CoV2 induced pneumonia. At admission, all had immunosuppression withdrawn and were started on methylprednisolone 16 mg/day, all but one was commenced on antiviral therapy and hydroxychloroquine with doses adjusted for kidney function.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Editorial: Special Report Source Type: research
More News: Bone Marrow Transplant | Children | Dialysis | Health | Kidney Transplant | Kidney Transplantation | Learning | Organ Donation | Pneumonia | Transplant Surgery | Transplants | Universities & Medical Training | Urology & Nephrology