He Married His Kidney Donor. But Now, He Needs Another Kidney

Kyle Froelich’s first search for a donor kidney ended in a fairy tale romance. In 2010, Chelsea Clair decided to give her kidney to Froelich—a man she’d never met—after hearing through a mutual friend that both of his were failing. The pair began seeing each other every day as Clair went through the donor testing process and eventually started dating after the transplant was complete. Kyle’s health returned, and they got married three years later, making headlines across the country. Now, however, the Indiana couple is back in the news for a less celebratory reason: the kidney Chelsea donated is failing. If Kyle doesn’t get a new one within the next year, he says, he’ll be forced to go on dialysis. “We’ve done it before. You have to stay optimistic,” Kyle, 28, says of his second search. “I don’t ever worry about it. I just have faith that it’s going to happen. When it happens, it happens.” The first time around, it happened thanks to Chelsea. At age 12, Kyle was diagnosed with a condition that causes an antibody to collect in his kidneys, resulting in inflammation that makes it difficult for his organs to filter waste products from his blood. By 19, Kyle was in desperate need of a transplant. He began looking for a donor among family and friends, but his type O blood made it difficult to find the right match. Dozens of his loved ones were tested, but none was the right fit. “I’d ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Source Type: news

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Pneumocystis jirovecii pneumonia (PCP) remains an important cause of morbidity and mortality in kidney transplant recipients. While the acute phase toxicity in patients with PCP is well-characterized, there is a ...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
We present a female patient, 13 years old, with diagnosis of hepatocellular carcinoma of fibrolamellar type, which was rapidly evolving. The fibrolamellar hepatocellular carcinoma invaded more than 80% of the hepatic parenchyma without surgical possibility or liver transplantation. Measures applied corresponded to chemotherapy of 1 cycle of cisplatin 40 mg/s/5 days + vincristine 1.5 mg/m2/day, 5-fluorouracil, doxorubicin, and dexrazoxane. The case presented aggressive evolution of hepatocellular carcinoma, which led to acute liver failure, with hyperammonemia, sepsis, pulmonary focus plus septic shock, grade III-IV encepha...
Source: Gastrointestinal Tumors - Category: Gastroenterology Source Type: research
ConclusionsAlthough use of mTOR inhibitors has been considered to be complicated, our experience shows that, using low dosages, it is possible to obtain relevant clinical improvements, with a good profile of safety and tolerability.
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
CONCLUSIONS: Although use of mTOR inhibitors has been considered to be complicated, our experience shows that, using low dosages, it is possible to obtain relevant clinical improvements, with a good profile of safety and tolerability. PMID: 31124053 [PubMed - as supplied by publisher]
Source: Paediatric Drugs - Category: Pediatrics Authors: Tags: Paediatr Drugs Source Type: research
436Aim: Currently, there are no available tool able to non-invasively define the presence of transplanted pancreas graft rejection; therefore, graft biopsy is nowadays the only available diagnostic tool for pancreas graft rejection. The aim of the present study is to assess the role of 18F-FDG PET-CT in detecting and monitoring pancreas graft rejection. Materials and Methods: Retrospective study including 12 patients (6M and 6F; mean age at transplant: 45±12 yrs; mean duration of diabetes 24±11yrs) who underwent pancreas transplantation alone (PTA) or simultaneous pancreas-kidney transplant (SPK) in the past....
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: NETs, BAT and All That Source Type: research
Feixia Zheng1*, Xiuyun Ye1, Xulai Shi1, Zhongdong Lin1, Zuqin Yang1 and Longxiang Jiang2* 1Department of Pediatrics, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China 2Department of Respiratory Medicine, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China Background: Hyponatremia has frequently been described as a common complication associated with bacterial meningitis, though its frequency and clinical course in children with bacterial meningitis are unclear. The present study aimed to investigate the frequen...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Herein, we report a rare case of severe respiratory syncytial virus pneumonia after kidney transplant in a 46-year-old woman. The patient was diagnosed with end-stage renal disease and underwent living-donor kidney transplant. Direct flow cytometry crossmatch testing yielded positive results, and desensitization treatment with rituximab, plasmapheresis, and im-munoglobulin was performed before transplant. There were no complications. Five days after discharge, the patient was readmitted with a 2-day history of fever and diagnosed with bilateral pneumonia. The patient was placed on mechanical ventilation a...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
Trimethoprim-sulfamethoxazole (TMP-SMX) is the drug of choice for anti-Pneumocystis jirovecii pneumonia (PcP) prophylaxis in kidney transplant recipients (KTR). Post-transplant management balances preventing PcP ...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
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