The Relevance of Vascular Endothelial Growth Factor, Hypoxia Inducible Factor-1 Alpha, and Clusterin in Carotid Plaque Instability

Background: Stroke is one of the leading causes of morbidity and mortality. Thromboembolism, as a major cause of carotid artery-related stroke, can be caused by plaque rupture which is associated with neoangiogenesis within the carotid plaque. Aim: We sought to investigate a possible correlation between angiogenesis-related factors and preoperative neurological manifestations in patients with internal carotid artery stenosis, for a better understanding of thromboembolism in internal carotid artery stenosis-related stroke.

Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2019 Category: Neurology Authors: Jelena Basic, Stefan Stojkovic, Afshin Assadian, Sabine Rauscher, Nikolaus Duschek, Christoph Kaun, Johann Wojta, J ürgen Falkensammer Source Type: research