Donor-derived CIK Cell Infusion as Consolidation after Non-myeloablative Allogeneic Transplant for Myeloid Neoplasms

Reduced intensity (RIC) and non-myeloablative (NMA) conditioning regimens are often utilized for patients with myeloid neoplasms of older age or with concurrent comorbid conditions undergoing allogeneic hematopoietic cell transplant (allo-HCT) due to high incidence of treatment related toxicity with myeloablative conditioning. In an analysis of 61 patients with myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), or therapy-related myeloid neoplasms (t-MN) undergoing NMA conditioning combining total lymphoid irradiation (TLI) with anti-thymocyte globulin (ATG) [1 –3], 3-year overall survival (OS) was 41% with 3-year non-relapse mortality (NRM) of 11% [2].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research