Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T  cell immunity

ConclusionOur data show the importance of specific expression of Notch ligands on DCs in the regulation of T-cell effector function. Thus, strategies incorporating selectively engineered Notch ligands could provide a novel approach of therapeutics for modulating immunity in various immunosuppressive conditions including cancer.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research