Increasing Prevalence of Untypable and Mixed Genotypes of Hepatitis C Virus in Pakistan: Latest Trends in 2018
Viral Immunology, Ahead of Print.
Journal of Interferon&Cytokine Research, Ahead of Print.
Publication date: January 2020Source: Microchemical Journal, Volume 152Author(s): Jenny Jeehan Nasr, Shereen ShalanAbstractUse of quantitative NMR (qNMR) is increasing nowadays for the determination of active pharmaceutical drugs in their bulk drug raw materials and in pharmaceutical formulations. In the present study, the advantages of two techniques of qNMR were exploited to assay three anti-hepatitis drugs, namely, daclatasvir by 1H-NMR, sofosbuvir, and ledipasvir by 19F-NMR in bulk drugs and in tablet dosage forms. The method was performed using phloroglucinol and norfloxacin as internal standards for 1H-NMR and 19F-NM...
Even with help, safety-net primary care clinics serving low-income and uninsured populations in the U.S. often fall short in screening baby boomers for hepatitis C virus (HCV), as recommended by the U.S. Preventive Services Task Force, according to a new study.Reuters Health Information
Medicaid, the state-level public insurance in the United States, has widely differing criteria treatment for hepatitis C virus (HCV) such as stage of liver fibrosis, documented sobriety, and specialist consult...
We recently read the article by Corma-G ómez A. et al. on which the authors described a higher probability of relapses with sofosbuvir/ledipasvir 8 weeks compared with 12 weeks of HCV (hepatitis C virus) among HIV (human immunodeficiency virus)/HCV coinfected patients.1 In this regard, coinfections of HIV/ HCV also with hepatitis B virus (HBV) is associated with high mortality and comorbidity too. The persistence of HBV DNA within the core cell in the absence of HBsAg and even after clearance of the infection has been described previously in immunosuppressed patients, where HBV screening and prophylaxis is recommended.
This report describes progress in Georgia ’s hepatitis C elimination program and highlights efforts to promote HCV screening and treatment initiation on a national scale. Novel strategies, such as reflex HCV core antigen testing to confirm infection for persons who screened anti-HCV positive were implemented. Reflex testing helped to iden tify greater numbers of persons with active infection, however, treatment initiation rates among those identified with active infection decreased. Georgia has made progress towards eliminating hepatitis C, treating over 50,000 persons, approximately one-third of the number infected,...
Conclusion: HCV antigen and RNA tests were positive within a median of 2 months before the detection of antibodies and ALT elevation. These tests could be considered for HCV screening in high-risk MSM.
ConclusionOur study showed excellent efficacy with the safety profile of this drug combination in end-stage renal disease patients. However, larger prospective studies and multicenter randomized controlled trials are needed for further confirmation.
CONCLUSIONS An increased frequency of musculoskeletal manifestations, better than those reported in the medical literature, in patients infected with HBV and HCV was observed.
We investigated antibody responses to hepatitis C virus (HCV) antigens E1 and E2 and the relevance of animal models for vaccine development. We compared antibody responses to vaccination with recombinant E1E2 complex in heathy volunteers, non-human primates (NHPs), and mice