Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice.

CONCLUSION: We present evidence of altered mt-mRNA translation during cardiac hypertrophy in aged obesity. We build on these results by demonstrating the necessity of mtIF2 in maintaining oxidative characteristics of cardiac muscle cells.
PMID: 30928679 [PubMed - as supplied by publisher]

Source: Experimental Gerontology - March 26, 2019 Category: Geriatrics Authors: Lee DE, Perry RA, Brown JL, Rosa-Caldwell ME, Brown LA, Haynie WS, Rajaram N, Washington TA, Greene NP Tags: Exp Gerontol Source Type: research