In-hospital and long-term outcomes of HIV-positive patients undergoing PCI according to kind of stent: a meta-analysis

Background Pathogenesis of cardiovascular disease in HIV-positive patients is related to the interaction between traditional and HIV-specific factors. Limited data are available regarding the prognosis of HIV-positive patients undergoing percutaneous coronary intervention (PCI). Methods All observational studies evaluating the prognosis of HIV-positive patients treated with PCI were included. In-hospital and long-term major adverse cardiac events (MACE) [composite endpoint of all-cause death or myocardial infarction (MI)] were the primary endpoints, whereas in-hospital and long-term all-cause death, cardiovascular death, MI, stent thrombosis, target vessel revascularization (TVR), target lesion revascularization (TLR), and bleeding complications were the secondary ones. Findings In all, 1243 patients in nine studies were included, with a mean age of 54 years. Among them, 12% were female and 91% were admitted for acute coronary syndromes. In-hospital MACE occurred in 6.0% (5.4–6.6), death in 4.2% (2.6–5.9), and MI in 1.3% (0–2.8), whereas major bleeding occurred in 2.0% (1.7–2.3) of the patients. After 2 years (1.6–3.1), long-term MACE occurred in 17.4% (11.9–22.3), all-cause death in 8.7% (3.2–14.2), and MI in 7.8% (5.5–10.1) of the patients, whereas stent thrombosis and TVR in 3.4% (1.5–5.3) and 10.5% (7.5–13.4), respectively. In patients treated with drug-eluting stents (DES), the rate of long-term MACE was 22.3% (10.1–34.4), with an incidence ...
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research