Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula [Research Communications]

In this study, we found H3K27me3 is strongly biased toward the maternal allele with some associated with DNA methylation–independent paternally expressed genes (PEGs) in human morulae. The H3K27me3 domains largely overlap with DNA partially methylated domains (PMDs) and occupy developmental gene promoters. Thus, our study not only reveals the H3K27me3 landscape but also establishes a correlation between maternal-biased H3K27me3 and PEGs in human morulae.

Source: Genes and Development - March 31, 2019 Category: Genetics & Stem Cells Authors: Zhang, W., Chen, Z., Yin, Q., Zhang, D., Racowsky, C., Zhang, Y. Tags: Research Communications Source Type: research