PERSPECTIVES Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection

Hepatitis A virus (HAV) and hepatitis E virus (HEV) cause acute, self-limiting hepatic infections that are usually spread by the fecal–oral route in humans. Naturally occurring and experimental infections are possible in a variety of nonhuman primates and, in the case of HEV, a number of other species. Many advances in understanding the pathogenesis of these viruses have come from studies in experimental animals. In general, animals infected with these viruses recapitulate the histologic lesions seen in infected humans, but typically with less severe clinical and histopathological manifestations. This review describes the histopathologic changes associated with HAV and HEV infection in humans and experimental animals.
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Enteric Hepatitis Viruses PERSPECTIVES Source Type: research

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The objectives of this study were to 1) identify along the raspberry supply chain the most influential factors of E. coli and HAV contamination in the final products; and 2) evaluate the efficacies of possible interventions to control these influential factors. To achieve these objectives, a unified quantitative model of microbial contamination in raspberries was developed to describe the impact of factors in a continuum from the farm to the destination of importation on E. coli/HAV contamination in fresh and frozen raspberry products. Multiple surveys were conducted to obtain country-specific data on current common practi...
Source: Food Control - Category: Food Science Source Type: research
In this study, we assessed whether there were any survival advantages with a combination treatment of intravenousN-acetylcysteine (NAC) and prednisone over prednisone alone in those with severe alcoholic hepatitis [discriminant function (DF)  ≥ 32].Patients and MethodsBetween January 1, 2013, and February 28, 2019, we identified 68 patients (mean age 47.2  years ± 10.1, 57% women, 65% cirrhosis, MELD score 28.1 ± 6.6) with alcoholic hepatitis, and of those, 21 (31%) received prednisone and 47 (69%) received prednisone + NAC. Lille score &g...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Conclusions: The technique used was adequate to guide surveillance actions in the country and allows articulation between local surveillance efforts and other sectors to resolve health problems caused by infectious and parasitic diseases and associated factors. PMID: 32051684 [PubMed]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
We present a 13-year old previously healthy Omani with fatal hepatitis A virus infection. This case highlights the critical role of hepatitis A vaccination and argues for consideration of its inclusion in national vaccination programs in order to avert similar devastating consequences of yet another vaccine preventable disease.
Source: IDCases - Category: Infectious Diseases Source Type: research
Authors: Khoury T, Kadah A, Mari A, Sbeit W, Drori A, Mahamid M Abstract BACKGROUND: Autoimmune hepatitis (AIH) may be associated with other autoimmune diseases. Autoantibodies are common in AIH suggesting their potential role in the pathogenesis of the disease. Among these autoantibodies, thyroid autoantibodies have been reported in patients with chronic hepatitis, with greater prevalence in patients with chronic hepatitis C infection. OBJECTIVES: To assess the prevalence of thyroid dysfunction among patients with AIH. METHODS: In this case-control, retrospective study, we examined patients diagnosed with ...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Conclusions: Accounting for incident size, collaborating with the clinic network was more expensive than agency-wide emergency activation, though required fewer DOHMH personnel services.
Source: Journal of Public Health Management and Practice - Category: Health Management Tags: Research Reports: Research Brief Report Source Type: research
Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Changes include a recommendation for a hepatitis A catch-up vaccination for anyone who wasn't vaccinated as a child.News Alerts
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Infectious Diseases News Alert Source Type: news
Duck hepatitis A virus type 3 (DHAV-3) is one of the most harmful pathogens in the duck industry. However, the molecular mechanism underlying DHAV-3 infection in ducklings remains poorly understood. To study t...
Source: BMC Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
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