PERSPECTIVES Prostate Cancer Epigenetics: From Basic Mechanisms to Clinical Implications
A level of epigenetic programming, encoded by complex sets of chemical marks on DNA and histones, and by context-specific DNA, RNA, protein interactions, that all regulate the structure, organization, and function of the genome, is critical to establish both normal and neoplastic cell identities and functions. This structure–function relationship of the genome encoded by the epigenetic programming can be thought of as an epigenetic cityscape that is built on the underlying genetic landscape. Alterations in the epigenetic cityscape of prostate cancer cells compared with normal prostate tissues have a complex interplay with genetic alterations to drive prostate cancer initiation and progression. Indeed, mutations in genes encoding epigenetic enzymes are often observed in human cancers including prostate cancer. Interestingly, alterations in the prostate cancer epigenetic cityscape can be highly recurrent, a facet that can be exploited for development of biomarkers and potentially as therapeutic targets.
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): B. Choi, H. Jung, B. Yu, H. Choi, J. Lee, D. Kim
Conditions: Prostate Cancer; Treatment Interventions: Procedure: Focal therapy(Irreversible Electroporation); Procedure: Radical prostatectomy Sponsor: Shanghai East Hospital Not yet recruiting
This study aimed to evaluate whether IRE combining indoleamine 2,3-dioxygenase inhibitor (IDOi, Epacadostat) loaded iron oxide nanocarriers (IDOi-INCs) can serve as a magnetic resonance imaging (MRI) –guided local ablation strategy for enhancing prostate cancer immunotherapy.
The purpose of this study is to assess clinical outcomes of prostatic artery embolization (PAE) in men with localized prostate cancer (PCa) and lower urinary tract symptoms (LUTS) from benign prostatic hyperplasia (BPH).
We aimed to update the diagnostic yield of in-bore 3Tesla magnetic-resonance-guided biopsy (3T-MRGB) for prostate cancer (PCa) detection based on the assessment by recently described Prostate Imaging Reporting and Data System version 2.1(PIRADSv2.1).
We report 12-month outcomes from the TULSA-PRO Ablation Clinical Trial (TACT) pivotal study.
To evaluate the changes of 3 Tesla (3T) mpMRI and prostate-specific antigen (PSA) parameters before and during multiple time points after whole gland prostate cancer (PCa) treatment using MRI-guided directional transurethral ultrasound ablation (TULSA)
Focal laser ablation (FLA) for prostate cancer is usually performed in an MRI gantry, but can be performed outside MRI with transrectal ultrasound (TRUS) –MRI fusion. Relative costs were compared between the two approaches.
To evaluate the potential of sequential MR image –guided local immune checkpoint blockade immunotherapy using multifunctional carriers after a prechemotherapy in prostate cancer (PC).
For localized prostate cancer, a hypofractionated radiotherapy regimen that cuts treatment time in half continues to have noninferior efficacy long-term relative to a conventional radiotherapy regimen.Medscape Medical News