Medical News Today: What to know about tumor necrosis factor
Tumor necrosis factor is a protein involved in inflammation. Excess tumor necrosis factor (TNF) in the blood has a role in inflammatory conditions, such as forms of arthritis and irritable bowel disease. In this article, we look at TNF, its links with medical conditions, and how to reduce TNF levels.
ConclusionTwenty years after open rotator cuff repair, the rate of osteoarthritis was 29%. Massive rotator cuff tears were significantly associated with a higher rate of osteoarthritis. Less osteoarthritis was observed when suprasupinatus healed.Level of evidenceIV.
ConclusionArthroscopic stabilization of acute acromio-clavicular joint dislocation using a TightRope device is a minimally invasive procedure with decreased post-operative morbidity. It allows early rehabilitation and consistently provides a satisfactory outcome when performed in the acute phase of injury.
This study analysed the prevalence of cervical spine instability in Rheumatoid Arthritis (RA) patients following at a single centre in Basrah.Patients and methodsData were collected directly from patients through cervical spine examinations. Each patient was sent for dynamic (flexion and extension) lateral cervical radiographic imaging to assess the presence of atlantoaxial subluxation (AAS), superior migration of the odontoid (SMO) and sub-axial subluxation (SAS). Patients with positive radiographic findings were sent for MRI scans of the cervical spine to assess neurological compression.ResultsThe prevalence rate of cerv...
This study investigated the relationship between α7nAChR and RA development and the effects of SIN on α7nAChR expression in vivo and in vitro. Sprague-Dawley rats were injected with complete Freund's adjuvant to induce arthritis and then treated with SIN or methotrexate (MTX) from day 0 to day 30. Four clinical parameters-paw volume, arthritic index (AI), serum TNF-α concentration, and erythrocyte sedimentation rate (ESR)-were measured. Splenic lymphocytes were isolated for Bacille Calmette Guerin (BCG) stimulation. α7nAChR expression in tissues and cells was examined by RT-PCR, western blot, immuno...
We describe a case of CA-ECM in Portugal in an adult patient with discoid lupus erythematosus under immunomodulatory therapy. A 73-year-old woman was admitted to the emergency department with fever and altered mental status over 48 hours. Cerebrospinal fluid analysis showed 185 leukocytes/μL, including 85% neutrophils, hypoglycorrhachia (less than 5 mg/dL) and elevated protein of 423 mg/dL with positive culture for Escherichia coli. She was treated with ceftriaxone. Imaging studies also demonstrated spondylodiscitis and arthritis. She responded well to antimicrobial therapy and completed the treatment as an outpatient.
Conditions: Joint Diseases; Osteoarthritis, Hip; Rheumatoid Arthritis; Psoriatic Arthritis; Avascular Necrosis of Hip Intervention: Device: Routine Total Hip Arthroplasty Sponsor: Ortho Development Corporation Recruiting
Condition: IBS Interventions: Dietary Supplement: Probiotics; Other: Placebo Sponsor: Örebro University, Sweden Recruiting
Joints in the human body may be able to feel pain even when arthritis isn't present in the area, new research shows.
This article is protected by copyright. All rights reserved. PMID: 30729502 [PubMed - as supplied by publisher]
ConclusionsWe observed a psoriasis‐associated increased risk of CD and UC, which was higher in severe psoriasis, and an increased risk of psoriasis in patients with irritable bowel disease. Increased focus on gastrointestinal symptoms in patients with psoriasis may be warranted.