Blocking platelets: A possible option to prevent fatty liver disease and liver cancer

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Blood platelets which interact with liver cells and immune cells play a major role in the development of fatty liver disease, non-alcoholic fatty liver inflammation and liver cancer, scientists from the German Cancer Research Center (DKFZ) in Heidelberg and from Zurich University and University Hospital have now shown in a publication. The researchers have also worked out new approaches for using drugs to keep the development of fatty liver disease in check, thus preventing liver cancer in the long term.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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This study aims to explore the effective ingredients of RRP against CVDs, especially atherosclerosis (AS). Using the AutoDock Vina software, the RRP's ingredients were docked with the targets which can be collected by RCSB and UniProt. Then the screened ingredients and targets could be used to dispose the pathways by the Kyoto Encyclopedia of Genes and Genomes (KEGG). We used GEO, GCBI and DAVID databases to analyze the microarray data of AS which could be used to verify the results of molecular docking, all of which could show the molecular mechanism of RRP on CVDs. We also constructed a compound-target interaction networ...
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research
AbstractIncidence of non-alcoholic fatty liver disease (NAFLD) and liver cancer are 2 –3 times higher in males than females. Hormonal mechanisms are hypothesized, with studies suggesting that oophorectomy may increase risk, but population-based evidence is limited. Thus, we conducted a study within the Clinical Practice Research Datalink, with controls matched to cases of NAFLD (n  = 10,082 cases/40,344 controls) and liver cancer (n = 767 cases/3068 controls). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Effect measure modificatio...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
CONCLUSIONS: In this large cohort study, the presence and severity of NAFLD in normal-weight adults was associated with an increased incidence of diabetes independently of established risk factors. Indeed, isolated lean NAFLD was a stronger risk factor for incident diabetes than the presence of overweight/obesity without NAFLD. Subjects with lean NAFLD require careful monitoring for the development of metabolic abnormalities. PMID: 31176297 [PubMed - as supplied by publisher]
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
Authors: Parizadeh SM, Parizadeh SA, Alizade-Noghani M, Jafarzadeh-Esfehani R, Ghandehari M, Mottaghi-Moghaddam A, Goldani F, Khazaei M, Ghayour-Mobarhan M, Ferns GA, Hassanian SM, Avan A Abstract INTRODUCTION: Colorectal cancer (CRC) is a common malignancy, ranking fourth among the causes of cancer-related deaths globally. Its incidence has increased in recent decades, and now more than one million CRC patients are diagnosed and thousands die annually. The 5-year survival rate varies with the stage at diagnosis, are approximately 90% in the early stages of disease, and less than 10% in advanced disease. Non-alcoho...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Abstract N6-Methyladenosine (m6A) is the most abundant and important internal modification site of RNA methylation in viruses and eukaryotic. m6A RNA methylation plays key roles in the regulation of post-transcriptional gene expression, including messenger RNA (mRNA), microRNA (miRNA) and long noncoding RNA (lncRNA). And m6A methylation regulates the various aspects of RNA metabolism, including structure, maturation, stability, splicing, export, translation and decay. Liver is a vital metabolic and digestive organ in the pathophysiological processes. Recent studies suggested that m6A RNA modification highly regula...
Source: Analytical Biochemistry - Category: Biochemistry Authors: Tags: Anal Biochem Source Type: research
Filomena Corbo1†, Giacomina Brunetti2*†, Pasquale Crupi3, Sara Bortolotti4, Giuseppina Storlino4, Laura Piacente5, Alessia Carocci1, Alessia Catalano1, Gualtiero Milani1, Graziana Colaianni4, Silvia Colucci2, Maria Grano4, Carlo Franchini1, Maria Lisa Clodoveo6, Gabriele D'Amato7 and Maria Felicia Faienza5 1Department of Pharmacy-Drug science, University of Bari Aldo Moro, Bari, Italy 2Section of Human Anatomy and Histology, Department of Basic and Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy 3CREA-VE, Council for Agricultural Research and Economics&ndas...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In our 2018 editorial we outlined the major new challenges facing hepatology and the European Association for the Study of the Liver (EASL).1 Reference was made to the rapidly changing landscape of liver research, following the successful journey towards cure of hepatitis C virus (HCV), the rise of non-alcoholic fatty liver disease (NAFLD) and liver cancer and increasing attention to hepatitis B virus (HBV) infection ( “HBV cure”) and treatment of rare autoimmune and genetic liver diseases. It has also become clearer that society and governments play a critical role in the development of life-style related cond...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research
Conclusion Massive SI and immune cell paralysis associated with ACLF represent the extreme severity of CAID in response to an infectious or sterile challenge. The severe immune disturbance plays a pivotal role in the pathogenesis of the distinctive features of ACLF: organ failure and bacterial infection susceptibility. Excessive SI in ACLF results from the massive activation and dysfunction of an innate immune system challenged by increased PAMPs and DAMPs. SI leads to cell and tissue immunopathology contributing to hepatic and extrahepatic organ failure. Concomitantly, the course of ACLF is associated with a disproportio...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: While there is a certain overlap between the results of the current study and published transcriptomic profiles of non-transplanted livers with steatosis, we have identified discrete characteristics of the non-alcoholic fatty liver disease in liver grafts potentially utilizable for the establishment of predictive signature. Introduction Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in industrialized countries, its prevalence being estimated at 19–31.3% (1). It encompasses a range of conditions that are thought to arise from fatty liver (simple steatosis) throu...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Bianca Cox1†, Maria Tsamou1†, Karen Vrijens1, Kristof Y. Neven1, Ellen Winckelmans1, Theo M. de Kok2, Michelle Plusquin1 and Tim S. Nawrot1,3* 1Center for Environmental Sciences, Hasselt University, Hasselt, Belgium 2Department of Toxicogenomics, Maastricht University, Maastricht, Netherlands 3Department of Public Health, Environment and Health Unit, Leuven University (KU Leuven), Leuven, Belgium Maternal body mass index (BMI) before pregnancy is known to affect both fetal growth and later-life health of the newborn, yet the implicated molecular mechanisms remain largely unknown. As the master reg...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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