Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

In conclusion, our results support an integrated model for the Mad1 receptors in which the primary role of RZZ is to localize Mad1 at kinetochores to generate the Mad1-Bub1 complex.

Source: EMBO Journal - March 31, 2019 Category: Molecular Biology Authors: Zhang, G., Kruse, T., Guasch Boldu, C., Garvanska, D. H., Coscia, F., Mann, M., Barisic, M., Nilsson, J. Tags: Cell Cycle Articles Source Type: research