Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders.

Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders.
Behav Brain Res. 2019 Mar 26;:
Authors: Zabegalov KN, Khatsko SL, Lakstyga AM, Demin KA, Cleal M, Fontana BD, McBride SD, Harvey BH, de Abreu MS, Parker MO, Kalueff AV
Abstract
Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models. As rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to practical research advantages, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and stereotypic behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive behaviors in zebrafish, data on their genetic and pharmacological modulation, and the overall translational relevance of fish ARBs to modeling human brain disorders. Overall, the zebrafish is rapidly emerging as a new promising model to study ARBs and their underlying mechanisms.
PMID: 30926483 [PubMed - as supplied by publisher]

Source: Behavioural Brain Research - March 25, 2019 Category: Neurology Authors: Zabegalov KN, Khatsko SL, Lakstyga AM, Demin KA, Cleal M, Fontana BD, McBride SD, Harvey BH, de Abreu MS, Parker MO, Kalueff AV Tags: Behav Brain Res Source Type: research