Spatiotemporal Correlations between < b > < i > amh < /i > < /b > and < b > < i > cyp19a1a < /i > < /b > Transcript Expression and Apoptosis during Gonadal Sex Differentiation of Pejerrey, < b > < i > Odontesthes bonariensis < /i > < /b >

In this study, we investigated the spatiotemporal expression patterns ofamh, gonadal aromatase (cyp19a1a), and apoptosis in relation to the histological gradient in ovaries and testes at an intermediate, sexually neutral temperature. The location and timing of expression ofamh,cyp19a1a, and apoptosis seemed to be highly coordinated with the time of gonadal sex differentiation and the histological gradient of gonadal sex differentiation. Apoptosis occurred predominantly in the anterior region of the right gonads and is surmised to be a process to delay differentiation in this area compared to the left gonad, possibly as a means to ensure uniform development in both gonads. Aromatase expression early during development was noted even in putative XY males, supporting the notion of primacy of female development in pejerrey gonads. Thus, apoptosis may be particularly important to prevent discrepant gonadal differentiation in XY individuals where genetic pro-male (amhy), pro-female (cyp19a1a), and thermal stimuli may antagonize.Sex Dev

Source: Sexual Development - March 31, 2019 Category: Biology Source Type: research