Fabrication of antimicrobial curcumin stabilized platinum nanoparticles and their anti-liver fibrosis activity for potential use in nursing care

In this study, Platinum and curcumin were conjugated to direct curcumin into the liver. Curcumin platinum nanoparticles (C-PtNPs) were formed by changing curcumin concentration at pH 10. The successful formation of C-PtNPs was recognized with the help of Fourier transform infrared (FTIR) and UV–visible spectrophotometers. The particle size and morphology were studied with the help of dynamic light scattering (DLS) and High-resolution transmission electron microscopy (HR-TEM) respectively. The antimicrobial activity of C-PtNPs, was examined against gram positive and gram negative bacteria. Moreover, the NIH/3 T3 cells were used to test the C-PtNPs activity of modifying initial fibrosis indication. The favorable condition for the synthesis of CPt-NPs was by using curcumin 1.5 mM at pH 10. When compared with free curcumin, C-Pt-NPs exhibited higher activity for decreased production of collagen by NIH/3 T3 cells. Altogether, the formation of C-PtNPs by conjugation of platinum to curcumin is assuring for the curcumin directing to treat the hepatic fibrosis.Graphical Abstract
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research