The study on the safety and efficacy of amnion graft for preventing the recurrence of moderate to severe intrauterine adhesions

Publication date: Available online 30 March 2019Source: Genes & DiseasesAuthor(s): Changjiang Li, Aiqi Cai, Congcong Sun, Yanhua Mao, Benyuan Wu, Yingfeng Zhang, Yuhan Wang, Shanbi Zhou, Jia WangAbstractTranscervical resection of adhesion (TCRA) is the standard treatment for the intrauterine adhesions, but the recurrence of adhesions is a tough problem for the gynecologist. In addition, the therapeutic strategy after TCRA about prevention of recurrence remains controversial especially for the patients with moderate to severe intrauterine adhesions (IUAs). Hence, we designed this study to explore the safety and efficacy of fresh amnion grafts for preventing the recurrence after TCRA for patients with moderate to severe IUAs. One hundred patients with moderate to severe IUAs who presented with a history of hypomenorrhea, amenorrhea and infertility were included in the study from January 2015 to December 2017. Patients were divided into amnion group (52 patients) and chitosan group (48 patients). Fresh amnion grafts or intrauterine injections of chitosan were administered after TCRA. Transvaginal ultrasonography(TVUS) and hysteroscopy were performed at the first and third month after the operation. The surgical procedures for all patients were completed successfully without relevant complications. In amnion group, 8 patients exhibited relapse in the first month and 2 patients in three months after surgery; in chitosan group, 23 women exhibited relapse in the first month and 18 p...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research