Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels.

In conclusion, our data indicate the potent therapeutic of BPS in mitigating fibrosis through repairing renal microvessels and suppressing endothelial-mesenchymal transition (EndMT) progression after inhibiting inflammatory and oxidative stress effects. KEY MESSAGES: BPS could improve renal recovery through anti-inflammatory and anti-oxidative pathways. BPS could mitigate fibrosis through repairing renal microvessels and suppressing endothelial-mesenchymal transition (EndMT). PMID: 30923844 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30923844?dopt=Abstract

Source: Molecular Medicine - March 27, 2019 Category: Molecular Biology Authors: Li S, Wang Y, Chen L, Wang Z, Liu G, Zuo B, Liu C, Sun D Tags: J Mol Med (Berl) Source Type: research