Diagnostic and prognostic implications of parafibromin immunohistochemistry in parathyroid carcinoma.

Diagnostic and prognostic implications of parafibromin immunohistochemistry in parathyroid carcinoma. Biosci Rep. 2019 Mar 29;: Authors: Pyo JS, Cho WJ Abstract The aim of this study was to elucidate the diagnostic and prognostic implications of parafibromin immunohistochemistry (IHC) in parathyroid carcinoma (PC). We performed a meta-analysis to examine the rate of loss of parafibromin expression from 18 eligible studies. In addition, a diagnostic test accuracy review was conducted to investigate the diagnostic role of parafibromin in PC. The rates of loss of parafibromin expression were 0.522 (95% confidence interval [CI] 0.444-0.599), 0.291 (95% CI 0.207-0.391), 0.027 (95% CI 0.011-0.064), and 0.032 (95% CI 0.008-0.119) in PC, atypical parathyroid adenoma (APA), parathyroid adenoma (PA), and parathyroid hyperplasia, respectively. In the diagnostic test accuracy review for diagnosis of PC, the pooled sensitivity and specificity of parafibromin IHC was 0.53 (95% CI 0.46-0.59) and 0.96 (95% CI 0.95-0.97), respectively. The diagnostic odds ratio and the area under curve on summary receiver operating characteristic curve was 25.31 (95% CI 8.91-71.87) and 0.7954, respectively. In addition, the meta-analysis demonstrated that loss of parafibromin expression was significantly correlated with worse disease-free survival (hazard ratio 2.832, 95% CI 1.081-7.421). Loss of parafibromin IHC expression was significantly higher in PC than in APA,...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research