Methyl 3-(5-(prop-1-yn-1-yl)thiophen-2-yl)propanoate: A Rare Acetylene Derivative from Artemisia absinthium Root Essential Oil.

Methyl 3-(5-(prop-1-yn-1-yl)thiophen-2-yl)propanoate: A Rare Acetylene Derivative from Artemisia absinthium Root Essential Oil.
Nat Prod Commun. 2017 Apr;12(4):603-606
Authors: Polina D B, Marko S P, Niko S R
Abstract
Methyl 3-(5-(prop-l-yn-l-yl)thiophen-2-yl)propanoate (1), biosynthetically and structurally related to dehydromatricaria ester, was isolated from the root essential oil of Artemisia absinthium L. (0.7% of the total oil). This is the second record of this compound and the very first one regarding it as an essential-oil constituent. In this paper, we give details regarding its isolation, structural elucidation and gas chromatographic properties (RI on DB-5 MS column: 1694). The NMR-based identification of the compound was corroborated by simulation of its 'H- and "C-NMR spectra using a GIAO method (DFT level of theory). A tentative biosynthetic pathway, possibly leading to this compound, is also proposed.
PMID: 30520605 [PubMed - indexed for MEDLINE]

Source: Natural Product Communications - March 30, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research