Association between electroencephalogram changes and plasma clozapine levels in clozapine-treated patients

This retrospective observational study was performed to investigate electroencephalogram abnormalities in clozapine-treated patients with refractory schizophrenia or bipolar disorder. The electroencephalogram and plasma clozapine and norclozapine levels in 71 patients were measured on the same day. Fifty-nine patients (85.9%) had a diagnosis of schizophrenia, and 12 patients (14.1%) had a diagnosis of bipolar disorder. The mean daily clozapine dose was 242.9 ± 105.5 mg (range 25–500 mg), and the mean plasma clozapine and norclozapine levels were 429.4 ± 264.1 and 197.8 ± 132.6 ng/ml, respectively. Twenty-five patients (35.2%) were taking valproate in combination with clozapine. electroencephalogram abnormalities were found in 51 (71.8%) patients. No patient reported clinical seizures. Plasma clozapine level was significantly associated with electroencephalogram abnormalities and was identified as a significant predictor of electroencephalogram abnormalities in a logistic regression analysis. The plasma norclozapine levels of patients taking both clozapine and valproic acid were significantly lower than those of patients treated with clozapine alone. These results demonstrate that electroencephalogram abnormalities are closely correlated with plasma clozapine levels. Valproate reduced plasma norclozapine levels. Simultaneous monitoring of electroencephalogram and plasma clozapine levels w...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research

Related Links:

CONCLUSIONS: The current study shows how most individuals in Finland depend solely on income transfer payments after an onset of a severe mental disorder. PMID: 31722646 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
This week’s Psychology Around the Net explores positive morning affirmations to tell your reflection (yep!), offers tips for surviving holiday family gatherings, what hiding Instagram likes could mean for your mental health, and more. The 6 Best Things to Say to Yourself in the Mirror According to Mental Health Pros: Think of these morning affirmations as an act of self-care. It might feel awkward at first, but starting the day in front of your mirror, taking a deep breath, and saying to the reflection “I’m so proud of you” (or “I’m a f****** bad***!”) can boost your self-esteem, ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net Affirmations employees Family Holidays instagram managers Motivation Self Care Self-Esteem workplace Source Type: blogs
ConclusionsPatients who experienced a different level of participation in decision-making than desired more frequently had compulsory admissions. We propose to assess participation preferences each time a relevant treatment decision is about to be made and tailor care accordingly. We identified several factors leading to compulsory admissions that can be modified to prevent further coercive measures.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
Authors: Muneer A Abstract Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric conditions like major depressive disorder, bipolar disorder, and schizophrenia may be associated with accelerated cellular aging, indicated by shortened leukocyte telomere length (LTL), which could underlie this connection. Telomere shortening occurs with repeated cell division and is reflective of a cell's mitotic history. It is also influenced by cumulative...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Aydin O, Unal Aydin P, Arslan A Abstract This chapter presents an overview of accumulating neuroimaging data with emphasis on translational potential. The subject will be described in the context of three disease states, i.e., schizophrenia, bipolar disorder, and major depressive disorder, and for three clinical goals, i.e., disease risk assessment, subtyping, and treatment decision. PMID: 31705495 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSIONS: The PRS discriminates psychosis converters from nonconverters and modestly improves individualized psychosis risk prediction when added to a psychosis risk calculator. The schizophrenia PRS shows promise in enhancing risk prediction in persons at high risk for psychosis, although its potential utility is limited by poor performance in persons of non-European ancestry. PMID: 31711302 [PubMed - as supplied by publisher]
Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
Authors: Anagnostopoulos GC, Basta M, Vgontzas AN, Rigas AG, Vassiliadis VG, Baloyannis SJ, Koutsomitros TS Abstract Electromagnetic radiation influences in many ways humans and animals, while earthquakes are known to be related with electromagnetic phenomena. We recently showed that large earthquakes reduced admissions of psychiatric patients, whereas small earthquakes were associated with increased number of admissions. Our aim was to examine the effect of seismic-related electromagnetic activity on two chronic and severe psychiatric disorders varying in terms of etiology and treatment, i.e. bipolar disorder and ...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
Mendelian randomisation technique suggests cause-and-effect relationship exists between smoking and depression and schizophrenia Related items fromOnMedica Child mental health linked to families who struggle Bipolar disorder is frequently misdiagnosed as depression Family, friends and work key to mental wellbeing Forcible admissions to psychiatric care have soared Mental health patients being sent long distances for treatment
Source: OnMedica Latest News - Category: UK Health Source Type: news
European Journal of Human Genetics, Published online: 06 November 2019; doi:10.1038/s41431-019-0526-yA multimodal attempt to follow-up linkage regions using RNA expression, SNPs and CpG methylation in schizophrenia and bipolar disorder kindreds
Source: European Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
AbstractPurpose of ReviewWe review the ongoing research in the area of acute and transient psychotic disorders (ATPDs) with regard to their nosology, epidemiology, clinical description, genetics, and neurobiology, examining evidence for distinctiveness or otherwise of ATPDs. We further highlight the lacuna in research in ATPDs.Recent FindingsStudies on ATPDs as defined in the ICD 10 have been reported from different parts of the world, more so from the developing countries. There is consistent evidence that there exist a group of ATPDs that occur more commonly among females, are often precipitated by stressful life events ...
Source: Current Psychiatry Reports - Category: Psychiatry Source Type: research
More News: Bipolar | Mania | Psychiatry | Schizophrenia | Study