Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics".

Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics". Recent Pat Antiinfect Drug Discov. 2019 Mar 26;: Authors: Chavda V, Patel S Abstract Lyme's Disease (LD) is a severe rapidly growing broad spectrum chronic infection caused by the bacterium 'Borrelia (B.) burgdoferi', which can be easily transmitted through the bite of certain species of ticks. The prevalence of LD is swiftly mounting in present scenario in many countries from species to species. Although Lyme's infection is now detectable via serologic examination of early and late Lyme neuroborreliosis (LNB), the management of persistent symptoms is still fraught with quora of doubt and debate. LD is a multisystem spirochete which results after the dissemination of B. burgdorferi from a dermal inoculation site after a tick bite. Lyme's infection can easily be transmitted to the central nervous system and develop various neurological symptoms due to inflammation and autoimmune response from body delivers to life-threatening "Lyme Borreliosis". The neurological symptoms are well mixed, late and confusing to be diagnosed easily from other diseases. The use of anti-biotic with post Lyme infection with neurological complications is still a topic of debate. Babesiosisstates, Human ehrlichiosis' the two other diseases, are associated with the same ticks that spread the LD. However, the diagnosed prevalence of human cases is usually much lower than tha...
Source: Recent Patents on Anti-Infective Drug Discovery - Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

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PMID: 30992122 [PubMed - in process]
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Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Authors: Holmes CL, Shim D, Kernien J, Johnson CJ, Nett JE, Shelef MA Abstract In rheumatoid arthritis, an autoimmune inflammatory arthritis, citrullinated proteins are targeted by autoantibodies and thus thought to drive disease. Neutrophil extracellular traps (NETs) are a source of citrullinated proteins and are increased in rheumatoid arthritis and therefore also implicated in disease pathogenesis. However, not all NETs are citrullinated. One theory aiming to clarify the intersection of citrullination, NETs, and rheumatoid arthritis suggests that specific stimuli induce different types of NETs defined by citrull...
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Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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Source: EurekAlert! - Biology - Category: Biology Source Type: news
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