Deep Brain Stimulation: Remote Control Brain

We have the story of one woman who is taking part in an experiment on deep brain stimulation.
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news

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Condition:   Parkinson Disease Intervention:   Procedure: Brain signal data collection Sponsor:   Massachusetts General Hospital Not yet recruiting
Source: - Category: Research Source Type: clinical trials
ConclusionWe have integrated machine learning (ML) with computational modeling and simulations and developed an accurate predictive model to determine MRI gradient-field induced voltage levels on implanted DBS systems.
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
AbstractPurpose of ReviewThis paper reviews the current preclinical and clinical evidence for cerebellar deep brain stimulation for stroke rehabilitation.Recent FindingsWe have demonstrated the effectiveness of cerebellar stimulation for stroke rehabilitation in rodent models, which has been reproduced by other groups. Synaptogenesis, neurogenesis, and vicariation of function in the perilesional cortex likely contribute to the mechanistic underpinnings of the effectiveness of this therapy. A Phase I clinical trial investigating dentate nucleus stimulation for improvement of hemiparesis due to stroke is currently underway, ...
Source: Current Physical Medicine and Rehabilitation Reports - Category: Rehabilitation Source Type: research
Device titration is a major challenge when using deep brain stimulation (DBS) to treat behavioral disorders. Unlike in movement disorders, there is no reliable real-time clinical feedback for changes in complex behaviors resulting from DBS. Here, a female patient receiving DBS of the nucleus accumbens for the treatment of morbid obesity underwent cognitive testing via the flanker task alongside traditional methods of device titration. One set of stimulation parameters administered during titration resulted in acute cognitive improvement (p = 0.033) and increased frontal engagement as measured by electroencephalography (lef...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, we evaluated the utility of dopamine transporter (DAT) imaging and subthalamic nucleus (STN) activities as indicators of PD severity.Materials and methodsTwelve hemispheres of ten patients with PD who underwent deep brain stimulation (DBS) were included in this study. Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part 3 scores were used to evaluate clinical severity. The relationship between specific binding ratio (SBR) of DAT imaging and the root mean square (RMS) of STN micro-electrode recording (MER) was evaluated.ResultsA negative correlation was detected between the MDS-...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
We report two patients with tremor-dominant Parkinson’s disease (PD) treated with unilateral thalamotomy of the ventralis intermedius nucleus (Vim) combined with the subthalamic nucleus (STN)-DBS or the posterior subthalamic area (PSA)-DBS. One year after the surgery, thalamotomy of the area from the Vim to the PSA showed improvement not only in tremor but also in rigidity and akinesia. PSA- or STN-DBS with low intensity stimulation eliminated residual PD symptoms. Combined DBS and thalamotomy may provide long-term improvement of the majority of PD symptoms using lower therapeutic stimulation voltages.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
A 79-year-old man who had the surgery called it a "life changer."
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
ConclusionsSubject to validation within vivo measurements, neuromodulation through a heating mechanism of action by 10 kHz ‐DBS can indicate novel therapeutic pathways and strategies for dose optimization.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Basic Research Source Type: research
Publication date: Available online 12 February 2020Source: NeuronAuthor(s): Michelle J. Redinbaugh, Jessica M. Phillips, Niranjan A. Kambi, Sounak Mohanta, Samantha Andryk, Gaven L. Dooley, Mohsen Afrasiabi, Aeyal Raz, Yuri B. SaalmannSummaryFunctional MRI and electrophysiology studies suggest that consciousness depends on large-scale thalamocortical and corticocortical interactions. However, it is unclear how neurons in different cortical layers and circuits contribute. We simultaneously recorded from central lateral thalamus (CL) and across layers of the frontoparietal cortex in awake, sleeping, and anesthetized mac...
Source: Neuron - Category: Neuroscience Source Type: research
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