Is Alzheimer's disease linked to Herpes simplex virus type  1 infection? A mini‐review of the molecular correlation and the possible disease connections

In this mini ‐review, we summarize the evidence regarding the molecular correlation between Herpes simplex virus type 1 and Alzheimer's disease. There are many studies that discuss the link between Herpes simplex virus type 1 and Alzheimer's disease; however, there is no study focused on the molecular compon ent. Furthermore, we summarize the findings of the previous related case–control studies from 1990 up to the present day. In addition, we mentioned the management approaches of Alzheimer's disease through viral vaccination and prevention of infection. AbstractAlzheimer's disease (AD) is the most common neurodegenerative disease in the world. Several pathological pathways and genetic alterations have been linked to AD; however, the definitive cause of the disease remains unknown. Recently, an increasing body of evidence suggests that neurodegenerative diseases, including AD, might be triggered by microbial infections. Herpes simplex virus type  1 (HSV1) has been found in brain samples from dead AD patients. At some point of in their lifetime, every person comes into contact with HSV1, but when this enters the brain, it remains latent. However, it was observed that when a person becomes old, and there is a decline in their immunity, the l atent HSV1 virus becomes reactivated. The reactivated virus then causes damage to the neural cell DNA and disrupts the DNA repair system, leading to AD. The present review would provide a clear understanding of how HSV1 influences D...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: Review Article Source Type: research