Atrial and brain natriuretic peptides- benefits and limits of their use in cardiovascular diseases.

Atrial and brain natriuretic peptides- benefits and limits of their use in cardiovascular diseases. Curr Cardiol Rev. 2019 Mar 26;: Authors: Roxana ME, Georgică T, Ionuț D, Gianina M, Cristina F Abstract Natriuretic peptides, produced by cardiac myocytes, are regulators of the intravascular volume and blood pressure, also having neuroendocrine, metabolic and growth controlling effects. In heart failure, their synthesis increases exponentially as part of the neuroendocrine activation, but their beneficial effects are diminished. The paper reviews relevant data about their role as diagnosis and prognosis markers in heart failure, the hemodynamic and clinical benefits of their use as therapy in heart failure, together with the main adverse effects, information useful in daily clinical practice. Peptides non-specifically increase in extracardiac pathology and there is also provided data about the mechanisms of increase, the significance and threshold values to exclude cardiac dysfunction. PMID: 30914031 [PubMed - as supplied by publisher]
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research