MRI brain map links early brain atrophy to HIV

Based on brain MR images of people with the human immunodeficiency virus (HIV),...Read more on AuntMinnie.comRelated Reading: MRI measurements can change Parkinson's diagnosis MRI shows drug slows brain atrophy in MS patients Brain MRI shows long-term adverse effects of West Nile virus MRI advances detection of Zika-related brain abnormalities fMRI finds cognitive issues in HIV-positive patients
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Publication date: Available online 9 August 2020Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Kumar Udit Saumya, Deepak Kumar, Prateek Kumar, Rajanish Giri
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Authors: Colombo D, Pnevmatikou P, Melloni E, Keywood C Abstract INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting more than 10 million patients worldwide. Despite increasing improvements in disease management, a huge medical need still exists as its relentless progression cannot be delayed by current treatments. Therefore, scientists, clinicians, and pharmaceutical companies are hunting new drugs with 'disease-modifying' properties. AREAS COVERED: This review concentrates on new therapeutics - excluding cell and gene therapies - under investigation for PD with 'd...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
"Dopamine Agonist Phobia" in Parkinson's disease: when does it matter? Implications for non-motor symptoms and personalized medicine. Expert Rev Neurother. 2020 Aug 05;: Authors: Rota S, Boura I, Batzu L, Titova N, Jenner P, Falup-Pecurariu C, Chaudhuri KR Abstract INTRODUCTION: Dopamine agonists have been widely used to treat patients with Parkinson's disease, but concerns related to their well-known side effects might prevent their use even when indicated. In this review, the authors describe for the first time the concept of "Dopamine Agonist Phobia", a pharmacophobia that the authors bel...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Conclusions: This easy, minimally time consuming and effective procedure for isolating and quantifying plasma apoptotic bodies could help physicians to implement the use of such vesicles as a non-invasive tool to monitor apoptosis in patients with cerebrovascular and neurodegenerative diseases for prognostic purposes and for monitoring disease activity. PMID: 32765191 [PubMed]
Source: Biological Procedures Online - Category: Molecular Biology Authors: Tags: Biol Proced Online Source Type: research
Publication date: Available online 8 July 2020Source: Pharmacological ResearchAuthor(s): Geir Bjørklund, Maryam Dadar, George Anderson, Salvatore Chirumbolo, Michael Maes
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 1 August 2020Source: Journal of Pharmacological SciencesAuthor(s): L. Iovino, M.E. Tremblay, L. Civiero
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Deciphering the robustness of pyrazolo-pyridine carboxylate core structure-based compounds for inhibiting α-synuclein in transgenic C. elegans model of Synucleinopathy. Bioorg Med Chem. 2020 Sep 01;28(17):115640 Authors: Maqbool M, Rajvansh R, Srividya K, Hoda N Abstract Parkinson's disease (PD), a calamitous neurodegenerative disorder with no cure till date, is closely allied with the misfolding and aggregation of α-Synuclein (α -Syn). Inhibition of α-Syn aggregation is one of the optimistic approaches for the treatment for PD. Here, we carried out hypothesis-driven studies to...
Source: Bioorganic and Medicinal Chemistry - Category: Chemistry Authors: Tags: Bioorg Med Chem Source Type: research
Source: Clinical Interventions in Aging - Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research
It is possible to tailor the frequency of laser light to selectively disrupt the bonds or structure of particular arrangements of molecules - such as, say, the harmful protein aggregates found in neurodegenerative and other age-related conditions. Researchers here showcase early work into the disruption of amyloids, a class of altered of proteins that feature prominently in numerous conditions. The challenge in this sort of approach is usually not that of achieving the desired disruption, but rather doing so without the delivery of so much energy, released as heat, that the process kills surrounding cells and tissues. Past...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(University of California - Riverside) A research team led by scientists at the University of California, Riverside, has outlined how the Zika virus, which constituted an epidemic threat in 2016, suppresses the immune system of its host. The work provides valuable structural and functional information on the interaction between ZIKV and its host and offers a framework for the development of vaccines and antivirals.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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