MRI brain map links early brain atrophy to HIV

Based on brain MR images of people with the human immunodeficiency virus (HIV),...Read more on AuntMinnie.comRelated Reading: MRI measurements can change Parkinson's diagnosis MRI shows drug slows brain atrophy in MS patients Brain MRI shows long-term adverse effects of West Nile virus MRI advances detection of Zika-related brain abnormalities fMRI finds cognitive issues in HIV-positive patients
Source: Headlines - Category: Radiology Source Type: news

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Publication date: Available online 23 May 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Inmaculada Banegas, Ana B. Segarra, Isabel Prieto, Francisco Vives, Marc de Gasparo, Raquel Duran, Juan de Dios Luna, Manuel Ramírez-SánchezAbstractAminopeptidase A is responsible for the hydrolysis of angiotensin II and cholecystokinin. By measuring its activity we obtain a reflection of the functional status of its endogenous substrates. Dopamine coexists with these neuropeptides in striatum and prefrontal cortex. If the content of any of them is altered, the others and the functions they are involved in w...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: Available online 24 May 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Alejandra Lucía Marcos, Gerardo Raul Corradi, Luciana Romina Mazzitelli, Cecilia Irene Casali, María del Carmen Fernández Tome, Hugo Pedro Adamo, Felicitas de Tezanos PintoAbstractMutations in the ATP13A2 gene (PARK9, CLN12, OMIM 610513) were initially associated with a form of Parkinson's Disease (PD) known as Kufor Rakeb Syndrome (KRS). However, the genetic spectrum of ATP13A2-associated disorders was expanded in the last years, because it has been found to underlay variants of neuronal ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Authors: Seritan AL, Rienas C, Duong T, Delucchi K, Ostrem JL Abstract OBJECTIVE: Parkinson's disease (PD) is a quintessential neuropsychiatric condition in which anxiety and depressive symptoms are common and may precede motor manifestations. The authors explored the ages at onset of anxiety and depressive disorders among patients with PD evaluated by psychiatrists at a deep brain stimulation center. METHODS: Psychiatric diagnoses and ages at onset were collected via clinical interviews. The ages at PD diagnosis were ascertained by chart review. Onset ages for anxiety and depressive disorders (overall and for ...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
The U.S. diagnostic market celebrated three regulatory firsts last week.  1. FDA Authorizes Marketing of First Zika Test Until now, tests for detecting Zika virus immunoglobulin (IgM) antibodies in blood were only authorized for emergency use under FDA's Emergency Use Authorization (EUA) authority. On Thursday, the agency said it has authorized marketing of the ZIKV Detect 2.0 IgM Capture ELISA under the agency's traditional premarket authority. The test is manufactured by InBios International. “At the onset of the Zika virus outbreak, when little was known about the disease or how...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance IVD Source Type: news
ConclusionWe used gold nanoparticles loaded exosomes for in-vivo neuroimaging and present specific migration and homing to various brain pathologies including stroke, Parkinson's, Alzheimer's, Autism and healthy brains as a control. By this method, we visualized the migration and homing abilities of exosomes in long-term follow-up ad report that in pathological areas they home for more than 96 hours while in healthy brains they are being evacuated within 24 hours. Furthermore, we show that MSC-exo uses chemotaxis signaling to target the inflammatory areas in the brain.
Source: Cytotherapy - Category: Cytology Source Type: research
This article covers the pharmacological treatment of depression in PD; this involves standard antidepressant treatment such as selective serotonin reuptake inhibitors, tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors, and monoamine oxidase inhibitors. As with depression not associated with PD, most treatment is partially successful. Non-pharmacological approaches are also touched upon. Expert opinion: Most antidepressant therapy shows partial efficacy in patients with PD. However, there is a need for better study design as well as more comparative studies for the treatment of depression in PD. Bi...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Ghada Omar Tuffaha, Mamon M. Hatmal, Mutasem O. TahaAbstractThe kinase c-Jun N-terminal Kinase 3 (JNK3) plays an important role in neurodegenerative diseases. JNK3 inhibitors have shown promising results in treating Alzheimer's and Parkinson's diseases. This prompted us to model this interesting target via three established structure-based computational workflows; namely, docking-based Comparative Intermolecular Contacts Analysis (db-CICA), pharmacophore modeling via molecular-dynamics based Ligand-Receptor Contact A...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
ConclusionThese findings represent evidence of the lack of vRNA persistence in the reproductive tract, in ZIKV exposed and/or recently infected reproductive age women and could help simplify current guidelines.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Condition:   Parkinson Disease Intervention:   Other: Speech therapy Sponsors:   Radboud University;   Michael J. Fox Foundation for Parkinson's Research Enrolling by invitation
Source: - Category: Research Source Type: clinical trials
Contributors : Akinori Miyashita ; Hiroyuki Hatsuta ; Masataka Kikuchi ; Akihiro Nakaya ; Yuko Saito ; Tamao Tsukie ; Norikazu Hara ; Soichi Ogishima ; Nobutaka Kitamura ; Kohei Akazawa ; Akiyoshi Kakita ; Hitoshi Takahashi ; Shigeo Murayama ; Yasuo Ihara ; Takeshi Ikeuchi ; Ryozo KuwanoSeries Type : Expression profiling by arrayOrganism :Transcriptome analysis of post-mortem brain tissue specimens from three brain regions (BRs), entorinal, temporal and frontal cortices, of 71 Japanese brain-donor subjects to identify genes relevant to the expansion of neurofibrillary tangles. In total, 213 brain tissue specimens (= 71 sub...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
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