At 71, She ’ s Never Felt Pain or Anxiety. Now Scientists Know Why.

Scientists discovered a previously unidentified genetic mutation in a Scottish woman. They hope it could lead to the development of new pain treatment.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Genetics and Heredity Opioids and Opiates Pain-Relieving Drugs Anxiety and Stress University College London Scotland Jo Cameron The British Journal of Anaesthesia Source Type: news

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This study aimed to evaluate the effect of preoperative carbohydrate oral (CHO) loading on the postoperative metabolic and inflammatory response, perioperative discomfort and surgical clinical outcomes in open colorectal surgery compared with a conventional fasting protocol.MethodsFifty patients were randomly allocated to either the intervention group (CHO), to receive preoperative oral carbohydrate supplementation, or the control group (FAST), to undergo preoperative fasting. Insulin resistance, insulin sensitivity, the Glasgow Prognostic Score (GPS) and IL-6 levels were analysed at 06  h on the day of surgery (T1), ...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
AbstractPurposeTo evaluate the efficacy of retro-peribulbar and subconjunctival anesthesia associated with intravenous sedation in patients undergoing evisceration and orbital implant placement.MethodsThe charts of 217 patients who underwent evisceration with trans-scleral implant placement were reviewed. Midazolam and fentanyl were used for intravenous sedation. For local anesthesia, a combination of lidocaine with epinephrine and bupivacaine was injected into the retrobulbar, upper peribulbar, and subconjunctival areas. The intraoperative pain and need for supplemental anesthetic injection were recorded prospectively.Res...
Source: International Ophthalmology - Category: Opthalmology Source Type: research
The objective of this study was to evaluate the reproducibility and the consistency of a visual analogue scale for anxiety compared with the reference method, the State ‐Trait Anxiety Inventory (STAI).DesignObservational, prospective, monocentric study of 500 patients in the post ‐anaesthetist care unit. Anxiety was evaluated using both the visual analogue scale for anxiety and the STAI in perioperative patients. Consistency between the visual analogue scale for anxiety and the STAI, detection thresholds and factors predicting anxiety were researched.ResultsA correlation was found between the visual analogue scale for ...
Source: Nursing Open - Category: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research
Discussion: Target-controlled infusion of remifentanil is an effective drug to reduce pain during CVC insertion in association with lidocaine-based local anesthesia, in conscious patients.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
For more than a century, clinicians have noticed a paradoxical phenomenon: certain patients who are taking opioids (which are supposed to numb pain) become more sensitive to pain than those who are not taking opioids. The earliest observation of this phenomenon can be traced back to the British physician Sir Clifford Allbutt, who, in 1870, described it: “at such times I have certainly felt it a great responsibility to say that pain, which I know is an evil, is less injurious than morphia, which may be an evil. Does morphia tend to encourage the very pain it pretends to relieve?” Research studies and clinical ob...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Pain Management Source Type: blogs
This study investigated the effect of blindfold training through the assessment of anxiety, delirium, and pain in children during the anesthesia recovery period. METHODS: This study was a prospective, randomized, controlled trial. Pediatric patients were randomized into either a control (routine practice) or blindfold training group (routine practice + blindfold training). Anxiety, delirium, and pain levels of children were assessed by the modified Yale Preoperative Anxiety Scale, Pediatric Anesthesia Emergence Delirium scale, and the Face, Legs, Activity, Cry, Consolability scale. FINDINGS: The blindfo...
Source: Journal of Perianesthesia Nursing - Category: Nursing Authors: Tags: J Perianesth Nurs Source Type: research
CONCLUSION: The use of Poloxamer 407 guarantees stability of the preparation, showing a reduction in oxidative reaction, and gives the gel the right texture for application to a bleeding wound. PMID: 31233867 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Sci Source Type: research
This week’s Psychology Around the Net covers ways you can be “good” at therapy (no joke), highlights an 11-year-old Montreal boy who created a video game to help kids understand mental health, how focusing on a few key habits can help keep you grounded when life gets hectic, recognizing postpartum depression in fathers, and more. Get to learning! Therapists Share 7 Ways You Can Be “Good” at Getting Therapy: No, this definitely is not about winning at therapy. You won’t find tips on how to make your therapist like you or trick your therapist into thinking you’re not as sad as you ac...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net anxiety esketamine goals habits Happiness Luke Toledo men and postpartum depression panic Spravato Therapy Video Games workplace Source Type: blogs
This study is a literature review on the physical and mental influence of hypnosis in pediatric patient in controlling anxiety and pain. The objective was to gather the evidence found in the analysis of articles, research and systematic reviews, in the period from 1994 to 2018. For a descriptive review were selected Internet portals as Medicine ®, Pubmed, Capes, using keywords like: “ hypnosis ” , “ pediatric dentistry ” , “ fear ” , “ anesthesia ” , “ anxiety ” , “ children ” , “ pain ” . Descriptively and concisely, they presented rel...
Source: RGO - Revista Gaucha de Odontologia - Category: Dentistry Source Type: research
Colonoscopy is essential for the diagnosis of many diseases, such as colorectal cancer, colorectal polyps and ulcerative colitis. Nevertheless, for the severe pain caused by colonoscopy, this examination is poorly tolerated. For people who have a very limit tolerance to anesthesia, it is important to find a method to ease their pain. Previous research found that music can reduce anxiety and pain during colonoscopy. The present study aimed to clarify the mechanism.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Saturday abstract Source Type: research
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