Cancer prevention drug also disables H. pylori bacterium

(Vanderbilt University Medical Center) A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Conclusion: This study demonstrates the unequal manifestation of EOGC within the two ethnic groups of Han and Yi. However, familial clustering was infrequent. Further investigations are necessary to discover relevant risk factors apart from hereditary predisposition. PMID: 32231466 [PubMed - in process]
Source: The Scientific World Journal - Category: Science Tags: ScientificWorldJournal Source Type: research
ConclusionOur findings support future studies to assess the association of differential antibody responses by race with risk of gastric cancer in the USA, which could then aid in developing targetedH. pylori eradication strategies.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
This study provides evidence showing that a combination of H. pylori infection and capsaicin consumption leads to gastric carcinogenesis mediated through interleukin-6 (IL-6) stimulation with an incidence rate of 50%. The anti-inflammatory role of DFMO highlights the injurious effect of inflammation in gastric cancer development and the need to reduce gastric inflammation for cancer prevention by inhibiting IL-6. Accordingly, preventive measures such as reduced capsaicin consumption, H. pylori clearance, and DFMO treatment may lessen gastric cancer incidence.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Cancers, Vol. 12, Pages 803: Helicobacter pylori Avoids the Critical Activation of NLRP3 Inflammasome-Mediated Production of Oncogenic Mature IL-1β in Human Immune Cells Cancers doi: 10.3390/cancers12040803 Authors: Suneesh Kumar Pachathundikandi Nicole Blaser Heiko Bruns Steffen Backert Helicobacter pylori persistently colonizes the human stomach, and is associated with inflammation-induced gastric cancer. Bacterial crosstalk with the host immune system produces various inflammatory mediators and subsequent reactions in the host, but not bacterial clearance. Interleukin-1β (IL-1β) is i...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Prinz C, Weber D Abstract Dysregulation of noncoding microRNA molecules has been associated with immune cell activation in the context of Helicobacter pylori induced gastric inflammation as well as carcinogenesis, but also with downregulation of mismatch repair genes, and may interfere with immune checkpoint proteins that lead to the overexpression of antigens on gastric tumor cells. Numerous miR-molecules have been described as important tools and markers in gastric inflammation and cancer development -including miR-21, miR-143, miR-145, miR-201, and miR-335- all of which are downregulated in gastric tumo...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study aimed to investigate the correlation between the four OMP genes (babA,oipA,sabA, andhomB) and gastroduodenal diseases. One hundred and seventy-sevenH. pylori strains were isolated from Chinese patients with different gastroduodenal diseases (49 chronic gastritis, 19 gastric ulcer, 33 gastric cancer, and 76 duodenal ulcer), 94 of which contained pathological information (41 superficial gastritis, 24 intestinal hyperplasia, and 29 gastric adenocarcinoma). The full-length amplification ofbabA,oipA,sabA,and homB genes was acquired and sequenced. Then, the genetic polymorphism was analyzed to compare with the referen...
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research
Lynch syndrome is the most common inherited cause of gastrointestinal cancer. Although current guidelines recommend endoscopic screening for gastric cancer and Helicobacter pylori infection in carriers of germline variants causing Lynch syndrome, there are limited data to support these recommendations.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Issue Highlights Source Type: research
Conclusions The ABC classification system is useful for predicting the risk of gastric cancer. However, this system was limited in group A, which included individuals with a high risk of developing gastric cancer. An endoscopic diagnosis of atrophy may be more effective than the ABC classification system for predicting the risk of gastric cancer. PMID: 32188803 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Abstract Gastric cancer is associated with chronic inflammation (gastritis) triggered by infection with the Helicobacter pylori (H. pylori) bacterium. Elevated tyrosine phosphorylation (pY) of the latent transcription factor STAT3 is a feature of gastric cancer, including H. pylori-infected tissues, and is aligned to nuclear transcriptional activity. By contrast, the transcriptional role of STAT3 serine phosphorylation (pS), which promotes STAT3-driven mitochondrial activities, is unclear. Here, by coupling pS-STAT3-deficient Stat3SA/SA mice with chronic H. felis infection, we reveal a key role for pS-STAT3 in pro...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
More News: Cancer | Cancer & Oncology | Gastric (Stomach) Cancer | Helicobacter Pylori