Incidence of Neoplasia in Pigs and Its Relevance to Clinical Organ Xenotransplantation.

Incidence of Neoplasia in Pigs and Its Relevance to Clinical Organ Xenotransplantation. Comp Med. 2019 Mar 25;: Authors: Jagdale A, Iwase H, Klein EC, Cooper DK Abstract As clinical pig organ xenotransplantation draws closer, more attention is being paid to diseases that affect pigs and thosethat provide a potential risk to human recipients of pig organs. Neoplasia arising from the pig organ graft is one such concern.Various tumors and other neoplastic diseases are well known to show increased incidence in organ allotransplant recipientsreceiving immunosuppressive therapy. Whether this effect will prove to be the case after xenotransplantation has not yetbeen established. Malignant tumors in young pigs are rare, with lymphosarcoma, nephroblastoma, and melanoma being the most common. The combination of noninvasive techniques and intraoperative examination of the pig organ likely will readilyconfirm that a pig organ graft is tumor-free before xenotransplantation. Posttransplantion lymphoproliferative disorder(PTLD) is a concern after allotransplantation, but the incidence after solid organ allotransplantation is low when compared with hematopoietic cell allotransplantation (for example, bone marrow transplantation), unless immunosuppressive therapy is particularly intensive. Organ-source pigs used for clinical xenotransplantation will be bred and housed under designated pathogen-free conditions and will be free of the γ-herpesvirus th...
Source: Comparative Medicine - Category: Zoology Authors: Tags: Comp Med Source Type: research