Think Sepsis

This e-learning resource for executive, non-executive and management level staff in trusts on sepsis, incorporates antimicrobial resistance and stewardship.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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ConclusionsDespite previous reports in Argentina, ST258 is no longer the absolute clone among KPC-Kp isolates. In the present study, dissemination of more virulent lineages such as the hypermucoviscous ST25 was detected. The emergence of the high-risk clone ST307 and occurrence of blaKPC-3 was noticed for the first time in this region.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
In this study, the key pharmacodynamic parameter (MIC) was determined for Pasteurella multocida and Mannhaemaia haemolytica isolated from ovine respiratory clinical cases using accepted laboratory methods for bacterial isolation, identification and MIC determination. In the case of Pasteurella multocida, for sulfamethoxazole/trimethoprim, MICrange, MIC50 and MIC90 values were 0.004–32 μg/mL, 0.063 μg/mL and 1 μg/mL; for tetracycline 0.016-256 μg/mL, 1 μg/mL, and 32 μg/mL; for enrofloxacin 0.002–32 μg/mL, 0.016 μg/mL and 0.5 μg/mL; for doxycycline 0.063–32 μg/mL, 1 μg/mL an...
Source: Small Ruminant Research - Category: Zoology Source Type: research
ConclusionThis is the first multicentre report of antifungal resistance rates among candidaemia isolates in Turkey, suggesting low resistance rates in general. Due to varying rates of fluconazole resistance in C. parapsilosis SC isolates that was detected at remarkably high levels in some centres, further studies are warranted to explore the source, clonal relatedness and resistance mechanisms of the isolates.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsTaken together, our results demonstrated that PAS resistance and mutations in katG, inhA promoter or oxyR-ahpC intergenic region in INH resistant M. tuberculosis has little effect on pasiniazid susceptibility.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsOur finding demonstrated that the fosB gene, mutations in the fosfomycin target enzyme MurA, and a high expression level of fosX were the resistance mechanisms in these enterococci.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Abstract SUMMARYHealth care-associated infections (HAIs) are a global problem associated with significant morbidity and mortality. Controlling the spread of antimicrobial-resistant bacteria is a major public health challenge, and antimicrobial resistance has become one of the most important global problems in current times. The antimicrobial effect of copper has been known for centuries, and ongoing research is being conducted on the use of copper-coated hard and soft surfaces for reduction of microbial contamination and, subsequently, reduction of HAIs. This review provides an overview of the historical and curre...
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
“This strain of tuberculosis (TB) is XDR-TB – extremely drug resistant tuberculosis– and is, as the name implies, highly resistant to the standard treatments,” says professor and TB/HIV expert Jason Farley, PhD, MPH, ANP-BC, AACRN, FAAN. HIV weakens the immune system, increasing the risk of TB in people with HIV. Dr. Farley’s Center, The REACH The post There’s a new cure for the deadliest strain of tuberculosis. So what’s that mean for the REACH Initiative’s HIV research in South Africa? appeared first on Johns Hopkins Nursing Magazine.
Source: Nursing Blogs at Johns Hopkins University - Category: Nursing Authors: Tags: On the Pulse antimicrobial resistance hiv REACH initiative TB tuberculosis Source Type: blogs
EMA, FDA and PMDA discuss regulatory approaches for the evaluation of new antibacterial agents (September 1-2, 2016 meeting summary)
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
ACC Abstract A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, an...
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
Authors: Moustakas I, Dryllis G, Pouliakis A, Petrikos G, Daikos G, Pittaras T, Karasante P, Karampotsis K, Tsiodras S Abstract Bacterial urogenital infections caused by multi-drug resistant organisms (MDROs), are increasingly becoming a severe public health issue. The purpose of the present study was to examine the epidemiology of recurrent UTIs along with antimicrobial resistance patterns in a cohort of patients followed as outpatients at an Infectious Disease clinic of a tertiary care center in Greece. One hundred, sequential patients suffering from recurrent UTIs and coming for clinical evaluation, follow-up an...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
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