Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features

Small bowel adenocarcinoma (SBA) is a rare neoplasm, which can occur in a sporadic form or can be associated with a number of predisposing conditions such as hereditary syndromes and immune-mediated intestinal...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research

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Publication date: Available online 2 October 2020Source: International Journal of Surgery Case ReportsAuthor(s): Gregory G. Tsiotos, Nikiforos Ballian, Fotios Milas, Panoraia Ziogou, Ilias Athanasiadis
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionsMismatch repair protein expression, histologic subtype, association with celiac disease, and, in the mismatch repair proficient subset only, T stage, may help identify patients who may benefit from adjuvant chemotherapy.Graphic Abstract
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
The incidence of small bowel cancers is increasing. Associations have been made between celiac disease and small bowel cancers, but there have been no detailed studies of large cohorts.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Conclusions: Our first data demonstrate the feasibility of FAP-targeted theranostics. PTRT using Lu-177 FAP-2286 is - due to long tumor retention - a highly promising treatment option in a broad spectrum of cancers. Further follow-up of patients as well as prospective clinical studies are warranted.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New Radiopharmaceuticals Source Type: research
ConclusionsTLILD2 could be a potential way to promote long-term survival of AEG patients. On the basis of the patterns of lymph nodes metastasis, we suggest that lower mediastinal and D2 celiac lymphadenectomy is necessary to improve the oncological outcome.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
To clarify the priority of lymph node dissection (LND) in advanced Siewert type II and III AEG, in which the center of the tumor is located below the esophagogastric junction (EGJ). Data in 395 patients with advanced Siewert type II or III AEG was analyzed retrospectively. The index of estimated benefit from LND (IEBLD) was used to evaluate the efficacy of LND for each nodal station. The mean number of dissected LNs did not differ significantly between patients with type II and III AEG, nor did the mean number of retrieved LNs at each station significantly differ between the 2 groups. According to the IEBLD, the dissecti...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Quality Improvement Study Source Type: research
Laura Stronati1, Francesca Palone2, Anna Negroni3, Eleonora Colantoni2, Anna Barbara Mancuso2, Salvatore Cucchiara2, Vincenzo Cesi3, Sara Isoldi2 and Roberta Vitali3* 1Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy 2Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy 3Division of Health Protection Technologies, Territorial and Production Systems Sustainability Department, ENEA, Rome, Italy Gut mucosal healing (MH) is considered a key therapeutic target and prognostic parameter in the management of inflammatory bowel disease (I...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractBackgroundWe analyzed the clinical impact of chemotherapy or chemoradiotherapy as initial treatment (IT), focusing on treatment duration, on morbidity and mortality in patients with resected pancreatic ductal adenocarcinoma.MethodsWe enrolled 509 consecutive patients, with 417 in the upfront surgery group and 92 in the IT group. The IT group was subdivided into 72 patients treated for
Source: Journal of Hepato-Biliary-Pancreatic Sciences - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
AbstractBackgroundWe analyzed the clinical impact of chemotherapy or chemoradiotherapy as initial treatment (IT), focusing on treatment duration, on morbidity and mortality in patients with resected pancreatic ductal adenocarcinoma.MethodsWe enrolled 509 consecutive patients, with 417 in the upfront surgery group and 92 in the IT group. The IT group was subdivided into 72 patients treated for
Source: Journal of Hepato-Biliary-Pancreatic Sciences - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
ConclusionsVenous thromboembolism during neoadjuvant therapy and the subsequent perioperative period is common and has a significant impact on outcome. Further study into novel thromboprophylaxis measures or protocols during neoadjuvant treatment and the perioperative period is warranted.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
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