Antiretroviral Hydrophobic Core Graft-Copolymer Nanoparticles: The Effectiveness against Mutant HIV-1 Strains and in Vivo Distribution after Topical Application

Conclusionsinsoluble orthogonal inhibitors of HIV-1 life cycle may be formulated into the non-aggregating ultrasmall NP which are highly efficient against NNRTI-resistant HIV-1 variant.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research

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Researchers from the U.K. may have developed a way to observe in vivo DNA damage...Read more on AuntMinnie.comRelated Reading: Travel cards could help radiopharma patients avoid delays FDG-PET leads prediction on neuroendocrine tumor outcomes Cu-64 DOTATATE PET could handle neuroendocrine tumors SNMMI: New therapy aids patients with neuroendocrine tumors Novel PET tracer shows promise for neuroendocrine tumors
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
FDG-PET has again proved its value by correlating positive neuroendocrine tumors...Read more on AuntMinnie.comRelated Reading: Cu-64 DOTATATE PET could handle neuroendocrine tumors PET/CT beats SPECT for neuroendocrine tumors SNMMI: New therapy aids patients with neuroendocrine tumors Novel PET tracer shows promise for neuroendocrine tumors SNMMI: PET/CT with Ga-68 DOTATOC targets neuroendocrine tumors
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Conditions:   HIV/AIDS;   Myocardial Infarction Interventions:   Radiation: Cardiac PET;   Radiation: 99mTc-tilmanocept SPECT/CT;   Radiation: Contrast Enhanced Coronary and Aortic Computed Tomography Angiography Sponsors:   Massachusetts General Hospital;   National Institutes of Health (NIH) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
PET/CT performed better than planar scintigraphy or SPECT for determining which...Read more on AuntMinnie.comRelated Reading: SNMMI: New therapy aids patients with neuroendocrine tumors Novel PET tracer shows promise for neuroendocrine tumors FDA approves new PET agent for rare neuroendocrine tumors Ga-68 DOTATATE PET/CT detects neuroendocrine tumor recurrence
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Abstract Brain imaging with MRI identifies structural cerebral pathology that may give rise to seizures. The greatest yield is from MRI at 3T using epilepsy protocols, and reported by expert neuroradiologists who possess the full clinical data. X-ray CT scanning has a role in assessing patients with seizures in the context of an acute neurological illness. Identifying a relevant structural lesion with MRI is fundamental in the consideration of epilepsy surgery; it is crucial to establish if a lesion is relevant to the epilepsy or not. If no lesion is identified, developmental MRI and image processing may identify ...
Source: Practical Neurology - Category: Neurology Authors: Tags: Pract Neurol Source Type: research
AbstractLiposome is one of the oldest yet most successful nanomedicine platforms. Doxil ®, PEGylated liposome loaded with doxorubicin (DOX), was approved by the FDA in 1995 for the treatment of AIDS-related Kaposi’s sarcoma, and it was the first approval for nanomedicine. Since then, liposome-based therapeutics were approved for the treatment of various diseases and many clinical tr ials are underway. The success of the liposome-based therapeutics was due to following factors: (1) ease of synthesis, (2) biocompatibility, (3) the ability to load both hydrophilic and hydrophobic agents, and (4) long circulation pro...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Myocardial perfusion cardiovascular MRI cannot top angiography and fractional...Read more on AuntMinnie.comRelated Reading: MRI aids in assessing cocaine-related heart damage AI model could enable gadolinium-free cardiac MRI Cardiac MRI flags signs of early heart disease in women Metastasis or incidental finding? Cardiac MRI gives answers Cardiac MRI beats SPECT for predicting heart events
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Cardiac MRI's ability to noninvasively provide a microscopic view of living...Read more on AuntMinnie.comRelated Reading: MRI shows brain changes from cannabis use MRI shows that cannabis alters youth brain development MRI reveals antipsychotic benefits of cannabis ARRS: DTI-MRI shows brain damage from cocaine use Brain SPECT shows improvement after cocaine users abstain
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
AbstractObjectiveWith the advancement of reperfusion therapy in stroke patients, assessment of perfusion status after therapy is gaining importance. Hyperperfusion tends to be underestimated by the conventional early imaging of123I-IMP brain perfusion SPECT. We evaluated the utility of super-early imaging as an adjunct to early imaging for the assessment of postischemic hyperperfusion in stroke patients.MethodsSixty-seven patients who underwent123I-IMP brain perfusion SPECT within 14 days after the onset of cerebral infarction were retrospectively analyzed. Super-early (4 –10 min) and early (15–45 min...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
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