Role of brain c ‐Jun N‐terminal kinase 2 in the control of the insulin receptor and its relationship with cognitive performance in a high‐fat diet pre‐clinical model

In conclusion, HFD and JNK2 absence cause alterations in normal cognitive activity by altering the signalling of the IR. These af fectations are related to the appearance of endoplasmic reticulum stress and an increase in the levels of inhibitory proteins like PTP1B and suppressor of cytokine signalling 3 protein.

Source: Journal of Neurochemistry - March 26, 2019 Category: Neuroscience Authors: Oriol Busquets, Àuria Eritja, Blanca M. López, Miren Ettcheto, Patricia R. Manzine, Rubén D. Castro‐Torres, Ester Verdaguer, Jordi Olloquequi, Manuel Vázquez‐Carrera, Carme Auladell, Jaume Folch, Antoni Camins Tags: Original Article Source Type: research