Defining Vitamin D Status Using Multi-Metabolite Mathematical Modelling: A Pregnancy Perspective

Publication date: Available online 26 March 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): C.H.L. Beentjes, J.P. Taylor-King, A. Bayani, C.N. Davis, J.L. Dunster, S. Jabbari, G.R. Mirams, C. Jenkinson, M. Kilby, M. Hewison, J.A. TamblynAbstractVitamin D deficiency is linked to adverse pregnancy outcomes such as pre-eclampsia (PET) but remains defined by serum measurement of 25-hydroxyvitamin D3 (25(OH)D3) alone. To identify broader changes in vitamin D metabolism during normal and PET pregnancies we developed a relatively simple but fully parametrised mathematical model of the vitamin D metabolic pathway. The data used for parametrisation were serum vitamin D metabolites analysed for a cross-sectional group of women (n = 88); including normal pregnant women at 1 st (NP1, n = 25) and 3rd trimester (NP3, n = 21) and pregnant women with PET (n = 22), as well as non-pregnant female controls (n = 20). To account for the effects various metabolites have upon each other, data were analysed using an ordinary differential equation model of the vitamin D reaction network. Information obtained from the model was then also applied to serum vitamin D metabolome data (n = 50) obtained from a 2nd trimester pregnancy cohort, of which 25 prospectively developed PET.Statistical analysis of the data alone showed no significant difference between NP3 and PET for serum 25(OH)D3 and 24,25(OH)2D3 concentrations. Conversely, a statistical an...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research