Cholesterol and cartilage do not mix well

Cholesterol and cartilage do not mix wellCholesterol and cartilage do not mix well, Published online: 26 March 2019; doi:10.1038/s41584-019-0204-zThe molecular mechanisms responsible for initiation and progression of osteoarthritis (OA) are incompletely understood. New data implicate cholesterol, its metabolites and the receptor RORα as catabolic drivers of OA-like disease in mice, but do these data identify new targets for treating patients with OA?

Source: Nature Reviews Rheumatology - March 25, 2019 Category: Rheumatology Authors: Frank Beier Source Type: research