Aspirin meets cGAS

Aspirin meets cGASAspirin meets cGAS, Published online: 26 March 2019; doi:10.1038/s41584-019-0205-ySensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?

http://feeds.nature.com/~r/nrrheum/rss/current/~3/5eP0lNhnQe8/s41584-019-0205-y

Source: Nature Reviews Rheumatology - March 25, 2019 Category: Rheumatology Authors: Keith B. Elkon Source Type: research

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