Transient Exocrine Pancreatic Insufficiency in Children: An Existing Entity?

Objectives: Pancreatic insufficiency in children is usually associated with diseases such as cystic fibrosis, Shwachman-Diamond syndrome, or chronic pancreatitis. Fecal elastase-1 is a reliable laboratory test for the diagnosis of exocrine pancreatic insufficiency (EPI). Transient pancreatic insufficiency has been rarely described and data on this entity are lacking in the medical literature. In this retrospective study we report 17 cases of transient pancreatic insufficiency presented mainly with failure to thrive and/or diarrhea. Methods: We followed 43 children (age range 1 month–18 years) with low fecal elastase-1 in our institution between the years 2009 and 2017. We followed growth and laboratory results (particularly, complete blood count, albumin, transaminases, celiac serology, sweat test, and fat-soluble vitamins). Elastase levels
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Pancreatology Source Type: research

Related Links:

Publication date: Available online 10 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Aabha Nagral, Moinak S. Sarma, John Matthai, Prashanth L. Kukkle, Harshad Devarbhavi, Sanjib Sinha, Seema Alam, Ashish Bavdekar, Radha K. Dhiman, Chundamannil E. Eapen, Vinay Goyal, Neelam Mohan, Rukmini M. Kandadai, Malathi Sathiyasekaran, Ujjal Poddar, Anupam Sibal, Srinivas Sankaranarayanan, Anshu Srivastava, Baburam R. Thapa, Pettarusp M. Wadia
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
This study assessed whether all BMS patients with ID (so-called ID/BMS patients) had iron deficiency anemia (IDA) and evaluated whether the ID/BMS patients had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects.Materials and methodsThe blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 143 ID/BMS patients and 442 healthy control subjects were measured and compared.ResultsWe found that 143 ID/BMS patients had significantly lower mean blood Hb and serum i...
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
Publication date: Available online 10 December 2019Source: Chinese Herbal MedicinesAuthor(s): Xiang-long Meng, Bo Wang, Chen-zi Lv, Cong Hu, Mei-jing He, Shuo-sheng ZhangABSTRACTObjectiveChinese yam (Shanyao in Chinese, SY) as one of the representatives for Chinese medicines can be used as both of medicine and food with rich nutritional and medicinal value. Most of Chinese herbal medicines need to be processed prior to be used in clinical practice. SY was divided into Maoshanyao (Hairy Shanyao, MSY) and Guangshanyao (Smooth Shanyao, GSY) based on different processing methods at the place of origin, and it also could be pro...
Source: Chinese Herbal Medicines - Category: Complementary Medicine Source Type: research
Conclusions: Promoting the socioeconomic status of the community, strengthening of home gardening, involving husbands in IYCF, and enhancing maternal knowledge of IYCF may advance DD. PMID: 31815015 [PubMed]
Source: Journal of Nutrition and Metabolism - Category: Nutrition Tags: J Nutr Metab Source Type: research
ConclusionsOlder patients with hematologic cancer are at high risk to experience depressive symptoms and low QoL. Health care professionals should assess geriatric symptoms and screen for depression to allow for early interventions and improve treatment outcomes.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Originally published in the Cornell ChronicleFolate is an essential B-vitamin that is needed for DNA synthesis and cell division. Folate deficiency can lead to anemia, and deficiency early in pregnancy can lead to neural tube defects – birth defects of the brain, spine and spinal cord, including spina bifida.A Cochrane systematic review on the benefits and safety of fortifying wheat or maize flour with folic acid and population health outcomes, led by scientists in the  Division of Nutritional Sciences at Cornell, found that fortification with folic acid (the synthetic form of folate) may improve folate sta...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
In this study, levels of vitamin D, calcium and phosphorus were evaluated in 51 normotensive pregnant women and 52 women with preeclampsia at the gestational age between 28 and 36 weeks in Tabriz. Logistic regression and general linear models were used for comparing levels and means of vitamin D, calcium and phosphorus between the two groups adjusting for education and Body Mass Index (BMI). The results showed that mean serum vitamin D (p = .73), calcium (p = .12) and phosphorus (p = .60) levels were not significantly different between the groups after adjusting for educatio...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
This study confirms the potential of MWP for producing low-fat dairy products.
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Pancreatic exocrine insufficiency occurs when there is insufficient production or delivery of pancreatic enzymes required for the digestion and absorption of food. It is associated with relatively poor outcomes, including reduced quality of life and survival.1 Common causes are cancer of the head/body of the pancreas, chronic pancreatitis, pancreatic resection and cystic fibrosis. It can occur following duodenectomy, gastrectomy or untreated coeliac disease via a reduction in cholecystokinin and thereby post-prandial pancreatic stimulation.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Summary AimsIn exocrine pancreatic insufficiency (EPI), the quantity and/or activity of pancreatic digestive enzymes are below the levels required for normal digestion, leading to maldigestion and malabsorption. Diagnosis of EPI is often challenging because the characteristic signs and symptoms overlap with those of other gastrointestinal conditions. Additionally, there is no single convenient, or specific diagnostic test for EPI. The aim of this review is to provide a framework for differential diagnosis of EPI vs other malabsorptive conditions. MethodsThis is a non‐systematic narrative review summarising information pe...
Source: International Journal of Clinical Practice - Category: Internal Medicine Authors: Tags: REVIEW ARTICLE Source Type: research
More News: Celiac Disease | Children | Coeliac Disease | Cystic Fibrosis | Gastroenterology | Laboratory Medicine | Nutrition | Pancreas | Pancreatitis | Pediatrics | Study | Vitamins