What can we do to prevent multidrug-resistance?

[What can we do to prevent multidrug-resistance?] Rev Argent Microbiol. 2019 Jan - Mar;51(1):1-2 Authors: Nastro M PMID: 30904052 [PubMed - in process]
Source: Revista Argentina de Microbiologia - Category: Microbiology Tags: Rev Argent Microbiol Source Type: research

Related Links:

Abstract In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3–7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of 1 was assisted by DFT-based theoretical chemical shift calculation. Compound 2 showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC of 125 µg/mL while 1 was not active...
Source: Beilstein Journal of Organic Chemistry - Category: Chemistry Authors: Tags: aromatic polyketide Fusarium marine fungus secondary metabolite sponge Full Research Paper Source Type: research
Authors: Severyn CJ, Brewster R, Andermann TM Abstract Growing evidence suggests that human microbiota likely influence diverse processes including hematopoiesis, chemotherapy metabolism, and efficacy, as well as overall survival in patients with hematologic malignancies and other cancers. Both host genetic susceptibility and host-microbiota interactions may impact cancer risk and response to treatment; however, microbiota have the potential to be uniquely modifiable and accessible targets for treatment. Here, we focus on strategies to modify microbiota composition and function in patients with cancer. First, we ev...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Conclusions: AEs were common, but not more frequent or severe among MDR-TB/HIV co-infected participants receiving concurrent antiretroviral therapy. Given the favorable treatment outcomes associated with concurrent treatment, antiretroviral therapy initiation should not be delayed in MDR-TB patients with HIV-coinfection.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Clinical Science Source Type: research
Publication date: Available online 5 December 2019Source: Plant ScienceAuthor(s): Jing Lin, Zejun Lan, Wenhuan Hou, Chunyan Yang, Dagang Wang, Mengchen Zhang, Haijian ZhiAbstractSoybean mosaic virus (SMV) is a major pathogen causing yield loss. Developing soybean plants tolerant or resistant to SMV is important for mitigating the adverse effects of the viral infection. However, most studies have focused on the resistance to normal SMV strains. Thus, investigations of the resistance or tolerance to the novel recombinant SMV strain have been limited. To address the threat of the recombinant SMV, two soybean parent genotypes ...
Source: Plant Science - Category: Biology Source Type: research
Publication date: Available online 5 December 2019Source: Carbohydrate PolymersAuthor(s): Tingsheng Yan, Jinmei He, Rongmei Liu, Zhonghua Liu, Jinju ChengAbstractCombination therapy provides an efficient way to overcome the potential multidrug resistance and enhance anticancer efficacy. In this work, a biodegradable pH-responsive hollow mesoporous silica nanoparticle (HMSN-GM-CS-FA) was developed for co-delivery of pheophorbide a (PA) and doxorubicin (DOX). This drug delivery system possessed controlled particle size and larger inner hollow core, which endowed the nanoparticle with excellent encapsulation capacities.The up...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
This study supports previous findings of multidrug resistance in commensal strains in rural communities and highlights the increased rates of resistance over time. We recommend studies in larger populations with a longer follow-up. PMID: 31800939 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
Conclusion: The effect of the synergic cytotoxic activity of both agents allowed to suppose that photoexcited C60 fullerene promoted Cis-Pt accumulation in leukemic cells resistant to Cis-Pt. The data obtained could be useful for the development of new approaches to overcome drug-resistance of leukemic cells. PMID: 31799157 [PubMed]
Source: BioImpacts - Category: Research Tags: Bioimpacts Source Type: research
CONCLUSIONS: These data suggest that PIP5K1A and PIP5K1C could be target proteins for modulating MRP2 function, partly because of the resulting changes of the linker function of radixin. PMID: 31804920 [PubMed - in process]
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Tags: J Pharm Pharm Sci Source Type: research
Publication date: Available online 5 December 2019Source: Research in Veterinary ScienceAuthor(s): Denise Damasceno Guerreiro, Laritza Ferreira de Lima, Naíza Arcângela Ribeiro de Sá, Gildas Tetaping Mbemya, Anna Clara Accioly Ferreira, Benner Geraldo Alves, Sarah Sant'anna Maranhão, Cláudia Pessoa, Alessandra Campbell Pinheiro, Thais Cristina Mendonça Nogueira, Marcus Vinícius Nora de Souza, José Ricardo de Figueiredo, Ana Paula Ribeiro RodriguesAbstractThe culture of preantral follicles as an in vitro model to evaluate the toxicity of new anticancer drug has being es...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
This article will review the available evidence in relation to prevention of sepsis in cUTI, evaluating the risk factors associated with sepsis development. Published articles from January 2005 to September 2019 on UTIs and sepsis prevention in complicated UTIs were identified by using MEDLINE (National Library of Medicine Bethesda MD) and by reviewing the references of retrieved articles.Expert opinion: Prevention of sepsis relies on prompt and timely diagnosis of cUTI, early identification of the causative organism, removal of obstructions and source control, proper and adequate empirical/targeted antimicrobial treatment...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
More News: Argentina Health | Microbiology | Multidrug Resistance